AUTHOR=Wu Xiaoting , Yang Xiangyu , Song Lulu , Wang Yang , Li Yamin , Liu Yuanyuan , Yang Xiaowei , Wang Yijun , Pei Weihua , Li Weidong 

TITLE=A Modified Miniscope System for Simultaneous Electrophysiology and Calcium Imaging in vivo

JOURNAL=Frontiers in Integrative Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2021.682019

DOI=10.3389/fnint.2021.682019

ISSN=1662-5145

ABSTRACT=Miniscope system is one of the calcium imaging tools with small size, lightweight, and can realize deep-brain calcium imaging not confined to the cerebral cortex. A combination of calcium imaging and electrophysiology recording has been an efficient method for extracting high temporal-spatial resolution signals in the brain. In this paper, A particular electrode probe was developed and assembled on the lens to modify the miniscope system. The electrode probe can be tightly integrated into the lens of the miniscope without increasing the volume, weight, and implantation complexity. In vivo tests verified that the proposed modified system had realized the simultaneous recording of calcium (Ca2+) signals and local field potential (LFP) signal in the hippocampus CA1 region of an adult mouse.