AUTHOR=Hernández-Echevarría Odelaisys , Cuétara-Lugo Elizabeth Bárbara , Pérez-Benítez Mario Jesús , González-Gómez Julio César , González-Diez Héctor Raúl , Mendoza-Santiesteban Carlos E. 

TITLE=Bi-nasal sectors of ganglion cells complex and visual evoked potential amplitudes as biomarkers in pituitary macroadenoma management

JOURNAL=Frontiers in Integrative Neuroscience

VOLUME=Volume 16 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2022.1034705

DOI=10.3389/fnint.2022.1034705

ISSN=1662-5145

ABSTRACT=The study was aimed to evaluate the retinal ganglion cell structure using OCT and the visual pathway function employing VEP in the diagnosis and monitoring of patients with PMA. A descriptive, cross-sectional and longitudinal study (3 and 12 months follow-up) was conducted on forty-two PMA patients. Thirty five age-matched healthy controls were used in the cross-sectional one. Full neuro-ophthalmological evaluation (structural and functional) was carried out including global and segmented RNFL/GCC analysis by OCT and VEP P100 amplitude and latency. Statistical data analysis was conducted with R version 3.6.3 and Python version 3.8. Associations were evaluated using Spearman correlations. VEP amplitudes sensitivities’ were 0.999 and global GCC and its bi-nasal sectors thickness’ specificities were 0.999. Bi-nasal of GCC had the highest diagnostic value (AUC = 0.923). Significant associations were found between global GCC and its bi-nasal sectors with VEP amplitude (Oz, 12’) (rho ˃ 0.7, p ˂ 0.01) and VF MD (rho ˃ 0.5, p ˂ 0.01); at three months. VEP amplitude and VF MD (rho ˃ 0.6, p ˂ 0.01), at 12 months had also a moderate association. Pre-surgical values of global and bi-nasal of GCC and VEP amplitude can predict post-surgically VF MD and VEP amplitude (Oz, 12’) at three months with r2 ˃ 0.5. Bi-nasal sectors of GCC and VEP P100 amplitude are efficient biomarkers of visual pathway damage for PMA patients’ management. Pre-surgical values of global GCC, bi-nasal sector of GCC, and VEP amplitude could help to predict the restoration of parvocellular pathway traffic after decompression.