AUTHOR=Ma Xiaoyu , Wang Juejin 

TITLE=Formononetin: A Pathway to Protect Neurons

JOURNAL=Frontiers in Integrative Neuroscience

VOLUME=Volume 16 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2022.908378

DOI=10.3389/fnint.2022.908378

ISSN=1662-5145

ABSTRACT=Formononetin is a phytoestrogen member of the flavonoid family,which has antioxidative, antihypertensive, antitumor, anti-infective, and estrogen-like pharmacological effects among others.FMN demonstrates potential in the prevention and treatment of diseases, specifically neurological diseases, such as traumatic brain injury, spinal cord injury ,ischemic stroke,cerebral ischemia-reperfusion,Alzheimer’s disease , and nerve tumor.A literature search is conducted to provide information on the signaling pathways of neuroprotection of formononetin based on the neuroprotective study.The significant neuroprotective function of FMN makes it a novel candidate for the development of drugs targeting the central nervous system.