Front. Mar. Sci. Frontiers in Marine Science Front. Mar. Sci. 2296-7745 Frontiers Media S.A. 10.3389/fmars.2022.1032381 Marine Science Opinion A transdisciplinary approach to reducing global plastic pollution Diana Zoie 1 Karasik Rachel 2 Merrill Greg B. 1 Morrison Margaret 1 Corcoran Kimberly A. 1 Vermeer Daniel 3 Hepler-Smith Evan 4 Jayasundara Nishad 5 Pare Jeremy 5 Virdin John 1 2 Eward William C. 6 Somarelli Jason A. 7 Dunphy-Daly Meagan M. 1 Rittschof Daniel 1 * 1 Duke University Marine Lab, Nicholas School of the Environment, Beaufort, NC, United States 2 Nicholas Institute for Energy, Environment & Sustainability, Duke University, Durham, NC, United States 3 Fuqua School of Business, Duke University, Durham, NC, United States 4 Department of History, Duke University, Durham, NC, United States 5 Nicholas School of the Environment, Duke University, Durham, NC, United States 6 Department of Orthopedics, Duke University Medical Center, Durham, NC, United States 7 Department of Medicine, Duke University Medical Center, Durham, NC, United States

Edited by: Richard M. K. Yu, The University of Newcastle, Australia

Reviewed by: Siu Gin Cheung, City University of Hong Kong, Hong Kong SAR, China

*Correspondence: Daniel Rittschof, ritt@duke.edu

This article was submitted to Marine Pollution, a section of the journal Frontiers in Marine Science

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 plastic pollution planetary boundaries interventions transdisciplinary policy microplastics additives sustainability Introduction

Plastic waste is ubiquitous in the environment – it can be found in sediments (Brandon et al., 2019), the atmosphere (Brahney et al., 2020; Evangeliou et al., 2020; Brahney et al., 2021), polar ice (Materić et al., 2022), the oceans (Eriksen et al., 2014; Fischer et al., 2015; Courtene-Jones et al., 2021), the human body (Ragusa et al., 2021; Zhang et al., 2021; Leslie et al., 2022), and in organisms across taxa. Without a new approach, about 710 million metric tons of plastics will enter the environment between 2016 and 2040 (Lau et al., 2020), leading to negative repercussions at all levels of biological organization (Bucci et al., 2020).

Global plastics production without sufficient waste management constitutes an “uncontrolled experiment” by humanity (Geyer et al., 2017). Based on trends in plastics production, plastics entering the environment, unwanted impacts on Earth system processes, and insufficient monitoring and safety assessment, Persson et al. (2022) assert that society has exceeded the planetary boundary for plastics. Though scientists are still determining proper control variables to measure the exceedance of this planetary boundary, immediate action is needed (Lau et al., 2020; Persson et al., 2022). Consistent with research needs (Villarrubia-Gómez et al., 2018; Persson et al., 2022), this article aims to 1) summarize the physical and chemical burdens posed by plastic pollution, focusing on the marine environment and society; 2) utilize the planetary boundaries approach as a call-to-action for global protection; and 3) suggest novel interventions to reduce plastic pollution, organized for the first time to our knowledge, by the four pathways toward global sustainability (Folke et al., 2021). We focus on the marine environment and society to understand impacts from plastics’ source, society, to a major sink – the ocean (Weiss et al., 2021).

 Plastics, plastics, everywhere

Plastics are synthetic organic polymers that provide many societal benefits (Andrady and Neal, 2009). Plastics are categorized by chemical/material properties and size. Macroplastics are >5 mm3 and include everyday items (e.g., furniture, textiles) (Khalid Ageel et al., 2022), fishing gear (Valderrama Ballesteros et al., 2018; Kuczenski et al., 2022), roads (Evangeliou et al., 2020; Brahney et al., 2021), pipes (Al-Malack, 2001), housing insulation (Huang and Tsuang, 2014), and paints (Dibke et al., 2021; Paruta et al., 2022) – plastics are ubiquitous.

Microplastics are < 5 mm3 (Arthur et al., 2009). Primary microplastics are intentionally produced (Rochman et al., 2019) and include pre-production pellets, synthetic turf (Thomas et al., 2019), and microbeads (Rochman et al., 2015). Secondary microplastics are generated through use or weathering (e.g., tire wear, microfibers) (Jahnke et al., 2017; Sobhani et al., 2020). Some ship hull coatings (Dibke et al., 2021; Turner, 2021) and biodegradable plastics (Wei et al., 2021) are engineered to produce microplastics.

 The physical and chemical burdens of marine plastic pollution

Microplastics enter the food web at all trophic levels (Cole et al., 2013; Desforges et al., 2015; Cox et al., 2019). Plastic ingestion can lead to abrasion, scarring (Neilson et al., 2009), perforation (Brandão et al., 2011; Wilcox et al., 2018), dismemberment (Law, 2017), restricted mobility (Neilson et al., 2009), suffocation (Gregory, 2009), and gastrointestinal obstruction (Stamper et al., 2009). Microplastics and nanoplastics (<100 nm) internalized via respiration or ingestion may translocate within the body (Browne et al., 2013; Pitt et al., 2018; Messinetti et al., 2019; Zeytin et al., 2020) and transfer across trophic levels (Nelms et al., 2018; Athey et al., 2020). Plastics ingestion and translocation may ultimately result in death (Bucci et al., 2020). Susceptibility depends on an animal’s life history, foraging ecology, and behavior, as well as plastics’ chemical composition, size, shape, and distribution (Allen et al., 2017; Savoca et al., 2017; Bucci et al., 2020; Diana et al., 2020).

At least 2,400 of the 10,000 compounds associated with plastics are toxins, endocrine disruptors, teratogens, or carcinogens (Hahladakis et al., 2018; Groh et al., 2019; Wiesinger et al., 2021). Depending on environmental conditions and chemical properties, plastics can leach plasticizers, contaminants, and proprietary compounds that are toxic to marine larvae (Li et al., 2016; Ward et al., 2022), impair embryonic development in fish, sea urchin, and mussels (Feng et al., 2012; Nobre et al., 2015; Gandara e Silva et al., 2016), and decrease the growth and photosynthetic capacity of important marine cyanobacteria (Tetu et al., 2019).

Proprietary organotins are used to produce certain plastics (e.g., polyesters, polyvinyl chloride) (Piver, 1973). Organotins are acutely toxic to marine animals at low concentrations (micrograms/liter), chronically toxic at lower concentrations (tens of nanograms/liter), and teratogenic and endocrine disrupting at very low levels (<10 nanograms/liter) (McClellan-Green et al., 2006). Plastics can adsorb environmental pollutants (e.g., heavy metals, persistent organic pollutants) (Rochman et al., 2013; Rochman et al., 2014), which may undergo trophic transfer (Athey et al., 2020). Society is not keeping pace with the safety assessments needed for chemicals associated with plastics (Wiesinger et al., 2021).

 The societal burden of plastic pollution: Human health and environmental justice

Microplastics have been reported in human lung tissue (Amato-Lourenço et al., 2021), stool and colectomy samples (Schwabl et al., 2019; Ibrahim et al., 2021), blood (Leslie et al., 2022), and placentas (Ragusa et al., 2021). Plastics impact humans health across levels of biological organization (Morrison et al., 2022), including molecular and cellular processes (Banerjee and Shelver, 2021), tissue and organ systems (Wright and Kelly, 2017), and physiological responses (Karbalaei et al., 2018). Studies characterizing plastics’ impact on human health are preliminary and primarily rely on laboratory experiments that simplify real-world exposures (WHO, 2022).

Marginalized communities are disproportionately exposed to plastic-associated pollutants (Calafat et al., 2008), which has recently received high-profile attention, including from the Biden administration in the United States (U.S.) (Singer, 2011; Keehan, 2018; Castellon, 2021). For example, “Cancer Alley” in Louisiana is an industrialized corridor of concentrated petrochemical and plastics manufacturing industries (U.S. EPA, 2014; Terrell and James, 2020). Residents have an increased cancer risk from air pollution compared to 95% of the U.S. population (U.S. EPA, 2014; Terrell and James, 2020). Over 20% of Cancer Alley residents live in poverty (Terrell and James, 2020), while the U.S. average in 2020 was 11.4% (Census.gov, 2022). Other environmental injustices include high-income countries exporting plastic waste to lower-income countries (Brooks et al., 2018; Kaza et al., 2018; Law et al., 2020), landfill citing locations (Bullard, 2018), impacts to indigenous peoples (e.g., land take, ecosystem destruction) (UNEP, 2021a), and occupational hazards to waste pickers (UNEP, 2021a). Marginalized communities often live and work in unsafe conditions due to exposure to transboundary plastic-associated pollutants.

 Discussion

Here we detail interventions to reduce plastic pollution ( Figure 1 ), which are organized for the first time (to our knowledge) by the four pathways toward global sustainability (Folke et al., 2021). This framework incorporates the interconnectedness of humans and nature to promote resilient, sustainable change (Folke et al., 2021). We focus on interventions infrequently discussed in the scientific literature because further innovation is needed to reduce plastic waste (Lau et al., 2020). Interventions should undergo small-scale experimentation to inform change at broader levels of governance (Folke et al., 2021). For this study, a team of interdisciplinary plastic pollution researchers selected interventions through discussion and review.

Suggested interventions organized by the four pathways toward global sustainability developed by Folke et al. (2021).

Pathway 1: “Recognize and act on the fact that societal development is embedded in and critically dependent on the biosphere” (Folke et al., 2021).

Raise public awareness about major sources of microplastics. Scientists recently found that paints (Dibke et al., 2021; Turner, 2021) and roads (Evangeliou et al., 2020) are significant microplastics sources (Lau et al., 2020; Paruta et al., 2022). Nongovernmental organizations should run campaigns or outreach programs to raise public awareness. Although non-plastic alternatives may not be available (or widespread) yet for paints and roads, awareness may help to spur action (e.g., research and development grants for alternatives). For example, social norms contributed to the voluntary phaseout of plastic microbeads in personal care products (Dauvergne, 2018a).

Create transparent disclosure systems. Management systems that provide transparency and accountability for the plastics value chain should be created, building on the Plastic Disclosure Project (2022). Corporate disclosures may accelerate science-based policy by reducing the opaqueness of global supply chains (Dauvergne, 2018b).

Pathway 2: “Create incentives and design policies that enable societies to collaborate towards just and sustainable futures within planetary boundaries” (Folke et al., 2021).

Apply the precautionary principle to the use of known toxins, carcinogens, and endocrine disrupters in plastics. Policies should require independent labs to test additives with unknown environmental and human health impacts before use, similar to the European Commission Regulation No 1223/2009 for cosmetics (EC, 2009). Findings should be shared publicly, potentially reducing the chances of regrettable substitution.

Incentivize alternatives. Policies that tax plastic products nudge consumer behavior to avoid plastics rather than to reflect its’ social cost (Rivers et al., 2017; Mogomotsi et al., 2019; Diana et al., 2022). Because determining plastics’ social cost is difficult, plastic should be priced at an estimate of the price necessary to meet plastics reduction targets by making alternatives more cost-effective (Monast and Virdin, 2022). Further investment should promote reusable alternatives. Governments should consider reducing perverse incentives (Sterner, 2003), such as subsidies or tax exemptions supporting unnecessary, problematic, or harmful plastics (UNEP, 2021b).

Develop a Science-Based Targets Initiative for plastics producers. Modeled off the Science-Based Targets Initiative (2021) for greenhouse gases, companies should adopt sector-specific targets backed by independent scientists to reduce plastic pollution. Targets should be specific, measurable, assignable, realistic, time-related (Doran, 1981), and adaptive.

Pathway 3: “Transform the current pathways of social, economic, cultural development into financially incentivized stewardship of human actions that enhance the resilience of the biosphere” (Folke et al., 2021).

Define sustainable plastics chemistry. Stakeholders should contribute to defining sustainable chemistry (Hogue, 2019) to inform safer plastics production (Anastas et al., 2021). Financial incentives could incentivize safer plastics production.

Match plastics’ half-life to use time. Governments should subsidize products that match plastic’s half-life to its approximate use time. For example, a plastic bag has a half-life of 4.6 years when buried on land (Chamas et al., 2020) but may only be used for hours. Measurement and reporting of plastics degradation time, microplastic generation, and degradation products should be standardized.

Pathway 4: “Make active use of emerging and converging technologies for enabling the societal stewardship transformation” (Folke et al., 2021).

Substitute harmful additives with bioelements. Biologically compatible elements (i.e., bioelements) should be used to generate polymers (Gadomska-Gajadhur and Ruśkowski, 2020) because biological systems use and maintain these molecules. Substantial removal of non-biocompatible compounds before selling a product should be required. Financial incentives could improve affordability.

Remove more plastic pollution than is produced. Similar to the CEO Water Mandate, which dictates a net positive impact on stressed watersheds (UN Global Compact, 2022), a voluntary program (van’t Veld and Kotchen, 2011) should be developed that requires companies to responsibly clean-up an excess of the plastic types produced. Plastic types should be organized by recycling category, a measure (e.g., weight per surface area), or product types. Clean-ups that utilize technologies to collect marine debris (Schmaltz et al., 2020; Dijkstra et al., 2021) should minimize bycatch and ecological impacts (Falk-Andersson et al., 2020). Recovered plastics should be recycled, repurposed, bioremediated (Sheth et al., 2019), or stored responsibly. This program may disincentivize unnecessary plastics production because plastics clean-up can be difficult and costly (Cordier and Uehara, 2019; Falk-Andersson et al., 2020). Monitoring and enforcement should supplement the program.

 Conclusions

Society has exceeded the planetary boundary for plastics – this can result in irreversible damage to the marine environment and human health due to physical and chemical burdens. The enormity of the problem and the remaining uncertainties of its effects should not deter us from action. Rather, we should redouble our efforts by connecting with experts across fields through open communication and a shared commitment to solutions. We must incorporate diverse viewpoints, including industry representatives and experts who are geographically distributed and be unafraid to test innovative approaches. This article shares novel strategies to add to the growing discourse (e.g., Bergmann et al., 2022; Zhu and Rochman, 2022) on tools to consider as we draft an international treaty to reduce plastic pollution (Simon et al., 2021). Through extensive cross-sector and transdisciplinary collaboration and transboundary coordination, society can begin to pave the way toward global plastics sustainability.

 Author contributions

ZD, DR, JV, JS and MD-D. conceived of the article. ZD, DR, MD-D, JV, EH-S, GM, JS, JP, KC, MM and RK contributed to writing the article. All authors contributed to the article and approved the submitted version.

 Funding

This work was funded through a pre-catalyst award from the Nicholas Institute for Environmental Policy Solutions (MD-D and JV) and Duke Bass Connections (JS). Open-access funding was obtained through Duke University Compact for Open Access Publishing Equity Fund (ZD). Research reported in this publication was supported by the National Institute Of Environmental Health Sciences of the National Institutes of Health under Award Number T32ES021432. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 Acknowledgments

We thank the Duke University Plastic Pollution Working Group for bringing the authors together.

 Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

 Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

 References Allen A. S. Seymour A. C. Rittschof D. (2017). Chemoreception drives plastic consumption in a hard coral. Mar. pollut. Bull. 124, 198–205. doi: 10.1016/j.marpolbul.2017.07.030 Al-Malack M. H. (2001). Migration of lead from unplasticized polyvinyl chloride pipes. J. Hazard Mater 82, 263–274. doi: 10.1016/s0304-3894(00)00366-6 Amato-Lourenço L. F. Carvalho-Oliveira R. Júnior G. R. dos Santos Galvão L. Ando R. A. Mauad T. (2021). Presence of airborne microplastics in human lung tissue. J. Hazardous Materials 416, 126124. doi: 10.1016/j.jhazmat.2021.126124 Anastas P. T. Saltzberg M. Subramaniam B. (2021). Plastics are not bad. bad plastics are bad. ACS Sustain. Chem. Eng. 9, 9150–9150. doi: 10.1021/acssuschemeng.1c03046 Andrady A. L. Neal M. A. (2009). Applications and societal benefits of plastics. Philos. Trans. R Soc. Lond B Biol. Sci. 364, 1977–1984. doi: 10.1098/rstb.2008.0304 Arthur C. Baker J. Bamford H. (2009) Proceedings of the international workshop on the occurrence, effects, and fate of microplastic marine debris (National Oceanic and Atmospheric Administration). Available at: https://marinedebris.noaa.gov/sites/default/files/publications-files/TM_NOS-ORR_30.pdf (Accessed March 5, 2020). Athey S. N. Albotra S. D. Gordon C. A. Monteleone B. Seaton P. Andrady A. L. . (2020). Trophic transfer of microplastics in an estuarine food chain and the effects of a sorbed legacy pollutant. Limnol. Oceanogr. Lett. 5, 154–162. doi: 10.1002/lol2.10130 Banerjee A. Shelver W. L. (2021). Micro- and nanoplastic induced cellular toxicity in mammals: A review. Sci. Total Environ. 755, 142518. doi: 10.1016/j.scitotenv.2020.142518 Bergmann M. Almroth B. C. Brander S. M. Dey T. Green D. S. Gundogdu S. . (2022). A global plastic treaty must cap production. Science 376, 469–470. doi: 10.1126/science.abq0082 Brahney J. Hallerud M. Heim E. Hahnenberger M. Sukumaran S. (2020). Plastic rain in protected areas of the united states. Science 368, 1257–1260. doi: 10.1126/science.aaz5819 Brahney J. Mahowald N. Prank M. Cornwell G. Klimont Z. Matsui H. . (2021). Constraining the atmospheric limb of the plastic cycle. Proc. Natl. Acad. Sci. U.S.A. 118, e2020719118. doi: 10.1073/pnas.2020719118 Brandão M. L. Braga K. M. Luque J. L. (2011). Marine debris ingestion by magellanic penguins, spheniscus magellanicus (Aves: Sphenisciformes), from the Brazilian coastal zone. Mar. Pollut. Bull. 62, 2246–2249. doi: 10.1016/j.marpolbul.2011.07.016 Brandon J. A. Jones W. Ohman M. D. (2019). Multidecadal increase in plastic particles in coastal ocean sediments. Sci. Adv. 5, eaax0587. doi: 10.1126/sciadv.aax0587 Brooks A. L. Wang S. Jambeck J. R. (2018). The Chinese import ban and its impact on global plastic waste trade. Sci. Adv. 4, eaat0131. doi: 10.1126/sciadv.aat0131 Browne M. A. Niven S. J. Galloway T. S. Rowland S. J. Thompson R. C. (2013). Microplastic moves pollutants and additives to worms, reducing functions linked to health and biodiversity. Curr. Biol. 23, 2388–2392. doi: 10.1016/j.cub.2013.10.012 Bucci K. Tulio M. Rochman C. M. (2020). What is known and unknown about the effects of plastic pollution: A meta-analysis and systematic review. Ecol. Appl. 30, e02044. doi: 10.1002/eap.2044 Bullard R. D. (2018). Dumping in Dixie: Race, class, and environmental quality. 3rd Edition (Routledge: Westview Press). Calafat A. M. Ye X. Wong L.-Y. Reidy J. A. Needham L. L. (2008). Exposure of the U.S. population to bisphenol a and 4-tertiary-octylphenol: 2003-2004. Environ. Health Perspect. 116, 39–44. doi: 10.1289/ehp.10753 Castellón I. G. (2021). Cancer alley and the fight against environmental racism. Vill. Envtl. LJ 32, 15. Census.gov (2022). Income and Poverty in the United States: 2020. Accessed: https://www.census.gov/library/publications/2021/demo/p60-273.html#:~:text=The%20official%20poverty%20rate%20in,from%2010.5%20percent%20in%202019. Chamas A. Moon H. Zheng J. Qiu Y. Tabassum T. Jang J. H. . (2020). Degradation rates of plastics in the environment. ACS Sustain. Chem. Eng. 8, 3494–3511. doi: 10.1021/acssuschemeng.9b06635 Cole M. Lindeque P. Fileman E. Halsband C. Goodhead R. Moger J. . (2013). Microplastic ingestion by zooplankton. Environ. Sci. Technol. 47, 6646–6655. doi: 10.1021/es400663f Cordier M. Uehara T. (2019). How much innovation is needed to protect the ocean from plastic contamination? Sci. Total Environ. 670, 789–799. doi: 10.1016/j.scitotenv.2019.03.258 Courtene-Jones W. Maddalene T. James M. K. Smith N. S. Youngblood K. Jambeck J. R. . (2021). Source, sea and sink–a holistic approach to understanding plastic pollution in the southern Caribbean. Sci. Total Environ. 797, 149098. doi: 10.1016/j.scitotenv.2021.149098 Cox K. D. Covernton G. A. Davies H. L. Dower J. F. Juanes F. Dudas S. E. (2019). Human consumption of microplastics. Environ. Sci. Technol. 53, 7068–7074. doi: 10.1021/acs.est.9b01517 Dauvergne P. (2018a). The power of environmental norms: Marine plastic pollution and the politics of microbeads. Environ. Politics 27, 579–597. doi: 10.1080/09644016.2018.1449090 Dauvergne P. (2018b). Why is the global governance of plastic failing the oceans? Global Environ. Change 51, 22–31. doi: 10.1016/j.gloenvcha.2018.05.002 Desforges J. W. Galbraith M. Ross P. S. (2015). Ingestion of microplastics by zooplankton in the northeast pacific ocean. Arch. Environ. Contamination Toxicol. New York 69, 320–330. doi: 10.1007/s00244-015-0172-5 Diana Z. Sawickij N. Rivera N. A. Hsu-Kim H. Rittschof D. (2020). Plastic pellets trigger feeding responses in sea anemones. Aquat. Toxicol. 222, 105447. doi: 10.1016/j.aquatox.2020.105447 Diana Z. Vegh T. Karasik R. Bering J. D. Llano Caldas J. Pickle A. . (2022). The evolving global plastics policy landscape: An inventory and effectiveness review. Environ. Sci. Policy 134, 34–45. doi: 10.1016/j.envsci.2022.03.028 Dibke C. Fischer M. Scholz-Böttcher B. M. (2021). Microplastic mass concentrations and distribution in German bight waters by pyrolysis–gas chromatography–mass Spectrometry/Thermochemolysis reveal potential impact of marine coatings: Do ships leave skid marks? Environ. Sci. Technol. 55, 2285–2295. doi: 10.1021/acs.est.0c04522 Dijkstra H. van Beukering P. Brouwer R. (2021). In the business of dirty oceans: Overview of startups and entrepreneurs managing marine plastic. Mar. Pollut. Bull. 162, 111880. doi: 10.1016/j.marpolbul.2020.111880 Doran G. (1981) There’s a S.M.A.R.T. way to write management’s goals and objectives. Available at: https://community.mis.temple.edu/mis0855002fall2015/files/2015/10/S.M.A.R.T-Way-Management-Review.pdf. Eriksen M. Lebreton L. C. M. Carson H. S. Thiel M. Moore C. J. Borerro J. C. . (2014). Plastic pollution in the world’s oceans: More than 5 trillion plastic pieces weighing over 250,000 tons afloat at Sea. PloS One 9, e111913. doi: 10.1371/journal.pone.0111913 European Commission (2009) Regulation (EC) no 1223/2009 of the European parliament and of the council of 30 November 2009 on cosmetic products (recast) (Text with EEA relevance)Text with EEA relevance. Available at: https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:02009R1223-20190813. Evangeliou N. Grythe H. Klimont Z. Heyes C. Eckhardt S. Lopez-Aparicio S. . (2020). Atmospheric transport is a major pathway of microplastics to remote regions. Nat. Commun. 11, 3381. doi: 10.1038/s41467-020-17201-9 Falk-Andersson J. Larsen Haarr M. Havas V. (2020). Basic principles for development and implementation of plastic clean-up technologies: What can we learn from fisheries management? Sci. Total Environ. 745, 141117. doi: 10.1016/j.scitotenv.2020.141117 Feng D. Rittschof D. Orihuela B. Kwok K. W. H. Stafslien S. Chisholm B. (2012). The effects of model polysiloxane and fouling-release coatings on embryonic development of a sea urchin (Arbacia punctulata) and a fish (Oryzias latipes). Aquat. Toxicol. 110–111, 162–169. doi: 10.1016/j.aquatox.2012.01.005 Fischer V. Elsner N. O. Brenke N. Schwabe E. Brandt A. (2015). Plastic pollution of the kuril–kamchatka trench area (NW pacific). Deep Sea Res. Part II: Topical Stud. Oceanogr. 111, 399–405. doi: 10.1016/j.dsr2.2014.08.012 Folke C. Polasky S. Rockström J. Galaz V. Westley F. Lamont M. . (2021). Our future in the anthropocene biosphere. Ambio 50, 834–869. doi: 10.1007/s13280-021-01544-8 Gadomska-Gajadhur A. Ruśkowski P. (2020). Biocompatible catalysts for lactide polymerization–catalyst activity, racemization effect, and optimization of the polymerization based on design of experiments. Organic Process Res. Dev. 24, 1435–1442. doi: 10.1021/acs.oprd.0c00149 Gandara e Silva P. P. Nobre C. R. Resaffe P. Pereira C. D. S. Gusmão F. (2016). Leachate from microplastics impairs larval development in brown mussels. Water Res. 106, 364–370. doi: 10.1016/j.watres.2016.10.016 Geyer R. Jambeck J. R. Law K. L. (2017). Production, use, and fate of all plastics ever made. Sci. Adv. 3, e1700782. doi: 10.1126/sciadv.1700782 Gregory M. R. (2009). Environmental implications of plastic debris in marine settings- entanglement, ingestion, smothering, hangers-on, hitch-hiking and alien invasions. Philos. Trans. R. Soc. B: Biol. Sci. 364, 2013–2025. doi: 10.1098/rstb.2008.0265 Groh K. J. Backhaus T. Carney-Almroth B. Geueke B. Inostroza P. A. Lennquist A. . (2019). Overview of known plastic packaging-associated chemicals and their hazards. Sci. Total Environ. 651, 3253–3268. doi: 10.1016/j.scitotenv.2018.10.015 Hahladakis J. N. Velis C. A. Weber R. Iacovidou E. Purnell P. (2018). An overview of chemical additives present in plastics: Migration, release, fate and environmental impact during their use, disposal and recycling. J. Hazardous Materials 344, 179–199. doi: 10.1016/j.jhazmat.2017.10.014 Hogue C. (2019). “Differentiating between green chemistry and sustainable chemistry in congress,” in Chemical & engineering news. Available at: https://cen.acs.org/environment/green-chemistry/Differentiating-between-green-chemistry-sustainable/97/web/2019/07. Huang Y.-C. T. Tsuang W. (2014). Health effects associated with faulty application of spray polyurethane foam in residential homes. Environ. Res. 134, 295–300. doi: 10.1016/j.envres.2014.07.015 Ibrahim Y. S. Tuan Anuar S. Azmi A. A. Wan Mohd Khalik W. M. A. Lehata S. Hamzah S. R. . (2021). Detection of microplastics in human colectomy specimens. JGH Open 5, 116–121. doi: 10.1002/jgh3.12457 Jahnke A. Arp H. P. H. Escher B. I. Gewert B. Gorokhova E. Kühnel D. . (2017). Reducing uncertainty and confronting ignorance about the possible impacts of weathering plastic in the marine environment. Environ. Sci. Technol. Lett. 4, 85–90. doi: 10.1021/acs.estlett.7b00008 Karbalaei S. Hanachi P. Walker T. R. Cole M. (2018). Occurrence, sources, human health impacts and mitigation of microplastic pollution. Environ Scie Poll Res 25 (36), 36046–36063. Kaza S Yao LC Bhada-Tata P Van Woerden F (2018). A Global Snapshot of Solid Waste Management to 2050. Urban Development;. Washington, DC: World Bank. https://openknowledge.worldbank.org/handle/10986/30317. License: CC BY 3.0 IGO. Keehan C. J. (2018). Lessons from cancer alley: How the clean air act has failed to protect public health in southern Louisiana. Colo. Nat. Resour. Energy Envtl. L. Rev. 29, 341. Khalid Ageel H. Harrad S. Abou-Elwafa Abdallah M. (2022). Occurrence, human exposure, and risk of microplastics in the indoor environment. Environ. Science: Processes Impacts 24, 17–31. doi: 10.1039/D1EM00301A Kuczenski B. Vargas Poulsen C. Gilman E. L. Musyl M. Geyer R. Wilson J. (2022). Plastic gear loss estimates from remote observation of industrial fishing activity. Fish Fish. 23, 22–33. doi: 10.1111/faf.12596 Lau W. W. Y. Shiran Y. Bailey R. M. Cook E. Stuchtey M. R. Koskella J. . (2020). Evaluating scenarios toward zero plastic pollution. Science 369, 1455–1461. doi: 10.1126/science.aba9475 Law K. L. (2017). Plastics in the marine environment. Annu. Rev. Mar. Sci. 9, 205–229. doi: 10.1146/annurev-marine-010816-060409 Law K. L. Starr N. Siegler T. R. Jambeck J. R. Mallos N. J. Leonard G. H. (2020). The united states’ contribution of plastic waste to land and ocean. Sci. Adv. 6, eabd0288. doi: 10.1126/sciadv.abd0288 Leslie H. A. van Velzen M. J. M. Brandsma S. H. Vethaak A. D. Garcia-Vallejo J. J. Lamoree M. H. (2022). Discovery and quantification of plastic particle pollution in human blood. Environ. Int. 163, 107199. doi: 10.1016/j.envint.2022.107199 Li H.-X. Getzinger G. J. Ferguson P. L. Orihuela B. Zhu M. Rittschof D. (2016). Effects of toxic leachate from commercial plastics on larval survival and settlement of the barnacle amphibalanus amphitrite. Environ. Sci. Technol. 50, 924–931. doi: 10.1021/acs.est.5b02781 Materić D. Kjær H. A. Vallelonga P. Tison J.-L. Röckmann T. Holzinger R. (2022). Nanoplastics measurements in northern and southern polar ice. Environ. Res. 208, 112741. doi: 10.1016/j.envres.2022.112741 McClellan-Green P. Romano J. Rittschof D. (2006). Imposex Induction in the Mud Snail, Ilyanassa obsoleta by Three Tin Compounds. Bull Environ Contam Toxicol 76, 581–588. doi: 10.1007/s00128-006-0959-1 Messinetti S. Mercurio S. Scarì G. Pennati A. Pennati R. (2019). Ingested microscopic plastics translocate from the gut cavity of juveniles of the ascidian Ciona intestinalis. The European Zoological Journal 86, 189–195. doi: 10.1080/24750263.2019.1616837 Mogomotsi P. K. Mogomotsi G. E. Phonchi N. D. (2019). Plastic bag usage in a taxed environment: Investigation on the deterrent nature of plastic levy in maun, Botswana. Waste Manag Res. 37, 20–25. doi: 10.1177/0734242X18801495 Monast J. Virdin J. (2022). “Pricing plastics pollution: Lessons from three decades of climate policy,” in Connecticut Law review. Connecticut Law Review. Available at: https://opencommons.uconn.edu/law_review/524. Morrison M. Trevisan R. Ranasinghe P. Merril G. B. Santos J. Hong A. . (2022). A growing crisis for One Health: impacts of plastic pollution across layers of biological function. Frontiers in Marine Science. doi: 10.3389/fmars.2022.980705 Neilson J. L. Straley J. M. Gabriele C. M. Hills S. (2009). A non-lethal entanglement of humpback whales ( megaptera novaeangliae ) in fishing gear in northern southeast Alaska. J. Biogeogr. 36, 452–464. doi: 10.1111/j.1365-2699.2007.01820.x Nelms S. E. Galloway T. S. Godley B. J. Jarvis D. S. Lindeque P. K. (2018). Investigating microplastic trophic transfer in marine top predators. Environ. pollut. 238, 999–1007. doi: 10.1016/j.envpol.2018.02.016 Nobre C. R. Santana M. F. M. Maluf A. Cortez F. S. Cesar A. Pereira C. D. S. . (2015). Assessment of microplastic toxicity to embryonic development of the sea urchin Lytechinus variegatus (Echinodermata: Echinoidea). Mar. pollut. Bull. 92, 99–104. doi: 10.1016/j.marpolbul.2014.12.050 Paruta P. Pucino M. Boucher J. (2022). Plastic paints the environment, EA- environmental action, ISBN 978-2-8399-3494-7. EA - Environmental Action. Persson L. Carney Almroth B. M. Collins C. D. Cornell S. de Wit C. A. Diamond M. L. . (2022). Outside the safe operating space of the planetary boundary for novel entities. Environ. Sci. Technol. 56, 1510–1521. doi: 10.1021/acs.est.1c04158 Pitt J. A. Kozal J. S. Jayasundara N. Massarsky A. Trevisan R. Geitner N. . (2018). Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio). Aquat. Toxicol. 194, 185–194. doi: 10.1016/j.aquatox.2017.11.017 Piver W. (1973). Organotin compounds: industrial applications and biological investigation. Environ. Health Perspect. 19, 61–79. doi: 10.1289/ehp.730461 Plastic Disclosure Project (2022). Available at: https://www.plasticdisclosure.org/understake-the-pdp. Ragusa A. Svelato A. Santacroce C. Catalano P. Notarstefano V. Carnevali O. . (2021). Plasticenta: First evidence of microplastics in human placenta. Environ. Int. 146, 106274. doi: 10.1016/j.envint.2020.106274 Rivers N. Shenstone-Harris S. Young N. (2017). Using nudges to reduce waste? the case of toronto’s plastic bag levy. J. Environ. Manage. 188, 153–162. doi: 10.1016/j.jenvman.2016.12.009 Rochman C. M. Brookson C. Bikker J. Djuric N. Earn A. Bucci K. . (2019). Rethinking microplastics as a diverse contaminant suite. Environ. Toxicol. Chem. 38, 703–711. doi: 10.1002/etc.4371 Rochman C. M. Hentschel B. T. Teh S. J. (2014). Long-term sorption of metals is similar among plastic types: Implications for plastic debris in aquatic environments. PloS One; San Francisco 9, e85433. doi: 10.1371/journal.pone.0085433 Rochman C. M. Hoh E. Hentschel B. T. Kaye S. (2013). Long-term field measurement of sorption of organic contaminants to five types of plastic pellets: Implications for plastic marine debris. Environ. Sci. Technol. 47, 1646–1654. doi: 10.1021/es303700s Rochman C. M. Kross S. M. Armstrong J. B. Bogan M. T. Darling E. S. Green S. J. . (2015). Scientific evidence supports a ban on microbeads. Environ. Sci. Technol. 49, 10759–10761. doi: 10.1021/acs.est.5b03909 Savoca M. S. Tyson C. W. McGill M. Slager C. J. (2017). Odours from marine plastic debris induce food search behaviours in a forage fish. Proc. Biol. Sci. 284, 20171000. doi: 10.1098/rspb.2017.1000 Schmaltz E. Melvin E. C. Diana Z. Gunady E. F. Rittschof D. Somarelli J. A. . (2020). Plastic pollution solutions: emerging technologies to prevent and collect marine plastic pollution. Environ. Int. 144, 106067. doi: 10.1016/j.envint.2020.106067 Schwabl P. Köppel S. Königshofer P. Bucsics T. Trauner M. Reiberger T. . (2019). Detection of various microplastics in human stool. Ann. Intern. Med. 171, 453–457. doi: 10.7326/M19-0618 Science-Based Targets Initiative (2021)Ambitious corporate climate action. In: Science based targets. Available at: https://sciencebasedtargets.org/ (Accessed April 8, 2021). Sheth M. U. Kwartler S. K. Schmaltz E. R. Hoskinson S. M. Martz E. J. Dunphy-Daly M. M. . (2019). Bioengineering a future free of marine plastic waste. Front. Mar. Sci. 6. doi: 10.3389/fmars.2019.00624 Simon N. Raubenheimer K. Urho N. Unger S. Azoulay D. Farrelly T. . (2021). A binding global agreement to address the life cycle of plastics. Science 373, 43–47. doi: 10.1126/science.abi9010 Singer M. (2011). Down cancer alley: The lived experience of health and environmental suffering in louisiana's chemical corridor. Med. Anthropol. Q. 25 (2), 141–163. doi: 10.1111/j.1548-1387.2011.01154.x Sobhani Z. Lei Y. Tang Y. Wu L. Zhang X. Naidu R. . (2020). Microplastics generated when opening plastic packaging. Sci. Rep. 10, 1–7. doi: 10.1038/s41598-020-61146-4 Stamper M. A. Spicer C. W. Neiffer D. L. Mathews K. S. Fleming G. J. (2009). Morbidity in a juvenile green sea turtle (Chelonia mydas) due to ocean-borne plastic. J. Zoo wildlife Med. 40, 196–198. doi: 10.1638/2007-0101.1 Sterner T. (2003). Policy instruments for environmental and natural resource management (Washington, DC: Resources for the Future: World Bank; Stockholm, Sweden : Swedish International Development Cooperation Agency, c2003). Available at: https://find.library.duke.edu/catalog/DUKE008570824. Terrell K. A. James W. (20221). Racial disparities in air pollution burden and COVID-19 deaths in Louisiana, USA, in the context of long-term changes in fine particulate pollution. Environ. Justice 15, env.2020.0021. doi: 10.1089/env.2020.0021 Tetu S. G. Sarker I. Schrameyer V. Pickford R. Elbourne L. D. Moore L. R. . (2019). Plastic leachates impair growth and oxygen production in prochlorococcus, the ocean’s most abundant photosynthetic bacteria. Commun. Biol. 2, 1–9. doi: 10.1038/s42003-020-0789-4 Thomas K. Irvin-Barnwell E. Guiseppi-Elie A. Ragin-Wilson A. Zambrana J. (2019). “Synthetic turf field recycled tire crumb rubber research under the federal research action plan,” in Final report part 1 - tire crumb rubber characterization appendices, vol. Volume 2. (Washington, DC: U.S. Environmental Protection Agency). Available at: https://cfpub.epa.gov/si/si_public_record_report.cfm?Lab=NERL&dirEntryId=346618. EPA/600/R-19/051.2. Turner A. (2021). Paint particles in the marine environment: An overlooked component of microplastics. Water Res. X 12, 100110. doi: 10.1016/j.wroa.2021.100110 UNEP (2021a). NEGLECTED: Environmental justice impacts of marine litter and plastic pollution (Nairobi: UNEP - UN Environment Programme). Available at: http://www.unep.org/resources/report/neglected-environmental-justice-impacts-marine-litter-and-plastic-pollution. UNEP (2021b). “From pollution to solution,” in A global assessment of marine litter and plastic pollution(Nairobi: The United Nations Environment Programme). UN Global Compact (2022) CEO Water mandate. Available at: https://ceowatermandate.org. U.S. EPA (2014) EJSCREEN: Environmental justice screening and mapping tool (US EPA). Available at: https://www.epa.gov/ejscreen (Accessed October 25, 2020). Valderrama Ballesteros L. Matthews J. L. Hoeksema B. W. (2018). Pollution and coral damage caused by derelict fishing gear on coral reefs around koh Tao, gulf of Thailand. Mar. pollut. Bull. 135, 1107–1116. doi: 10.1016/j.marpolbul.2018.08.033 van’t Veld K. Kotchen M. J. (2011). Green clubs. J. Environ. Economics Manage. 62, 309–322. doi: 10.1016/j.jeem.2011.03.009 Villarrubia-Gómez P. Cornell S. E. Fabres J. (2018). Marine plastic pollution as a planetary boundary threat–the drifting piece in the sustainability puzzle. Mar. Policy 96, 213–220. Ward C. S. Diana Z. Ke K. M. Orihuela B. Schultz T. P. Rittschof D. (2022). Microbiome development of seawater-incubated pre-production plastic pellets reveals distinct and predictive community compositions. Front. Mar. Sci. 8. doi: 10.3389/fmars.2021.807327 Wei X.-F. Bohlén M. Lindblad C. Hedenqvist M. Hakonen A. (2021). Microplastics generated from a biodegradable plastic in freshwater and seawater. Water Res. 198, 117123. doi: 10.1016/j.watres.2021.117123 Wiesinger H. Wang Z. Hellweg S. (2021). Deep dive into plastic monomers, additives, and processing aids. Environmental science & technology 55 (13), 9339–9351. Weiss L. Ludwig W. Heussner S. Canals M. Ghiglione J.-F. Estournel C. (2021). The missing ocean plastic sink: Gone with the rivers. Science 373, 107–111. doi: 10.1126/science.abe0290 Wilcox C. Puckridge M. Schuyler Q. A. Townsend K. Hardesty B. D. (2018). A quantitative analysis linking sea turtle mortality and plastic debris ingestion. Sci. Rep. 8 (1), 1–11. World Health Organization (WHO) (2022). Dietary and inhalation exposure to nano- and microplastic particles and potential implications for human health (Geneva: World Health Organization). Licence: CC BY- NC-SA 3.0 IGO. Wright S. L. Kelly F. J. (2017). Plastic and human health: A micro issue? Environ. Sci. Technol. 51, 6634–6647. Zeytin S. Wagner G. Mackay-Roberts N. Gerdts G. Schuirmann E. Klockmann S. . (2020). Quantifying microplastic translocation from feed to the fillet in European sea bass dicentrarchus labrax. Mar. pollut. Bull. 156, 111210. Zhang N. Li Y. B. He H. R. Zhang J. F. Ma G. S. (2021). You are what you eat: Microplastics in the feces of young men living in Beijing. Sci. Total Environ. 767, 144345. doi: 10.1016/j.scitotenv.2020.144345 Zhu X. Rochman C. (2022). Emissions inventories of plastic pollution: A critical foundation of an international agreement to inform targets and quantify progress. Environ. Sci. Technol, 3309–12. doi: 10.1021/acs.est.2c01038