AUTHOR=Zhou Yuwei , He Jingxin , Cui Hui 

TITLE=Terpenoids and other secondary metabolites produced by the Eutypella fungi and their bioactivities

JOURNAL=Frontiers in Marine Science

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/marine-science/articles/10.3389/fmars.2022.1074135

DOI=10.3389/fmars.2022.1074135

ISSN=2296-7745

ABSTRACT=The fungi of Eutypella could metabolize myriads of natural products with unique structures and diverse bioactivities, which were deemed as the key sources for lead compounds in drug discovery. Since the first research on Eutypella genus in 2009, myriads of secondary metabolites including terpenoids, alkaloids and polyketides have been discovered in this genus, and most of them exhibited significant pharmacological activities. However, there are no systematic reviews reported about their structures and bioactivities from the Eutypella up to now. In this review, a total of 153 secondary metabolites and 42 references have been systematically summarized, we found that the terpenoids (68.09%) and alkaloids (19.15%) were the main new components of this fungi, and the primary antiproliferative activity (64.89%) was mainly derived from the terpenoids and alkaloids. Thus, this review about the chemical diversity and biological activities of the metabolites from the fungus Eutypella provided a new perspective for the development of new drugs for pharmacologist.