AUTHOR=Hangad Maria Victoria , Keshvani Sarah , Kelpin Niya , Walters-Shumka Jonathan , Hood McKayla , Volk Cameo , Pal Danika , Willerth Stephanie M. TITLE=Using nanomaterials to address SARS-CoV-2 variants through development of vaccines and therapeutics JOURNAL=Frontiers in Materials VOLUME=Volume 9 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/materials/articles/10.3389/fmats.2022.1039247 DOI=10.3389/fmats.2022.1039247 ISSN=2296-8016 ABSTRACT=

Nanomaterials have played a significant role in effectively combating the global SARS-CoV-2 pandemic that began in December 2019 through the development of vaccines as well as antiviral therapies. These versatile, tunable materials can interact and deliver a broad range of biologically relevant molecules for preventing COVID-19 infection, generating immunity against COVID-19, and treating infected patients. Application of these nanomaterials and nanotechnologies can further be investigated in conjunction with disease models of COVID-19 and this holds immense potential for accelerating vaccine or therapeutic process development further encouraging the elimination of animal model use during preclinical stages. This review examines the existing literature on COVID-19 related nanomaterial applications, including perspective on nanotechnology-based vaccines and therapeutics, and discusses how these tools can be adapted to address new SARS-CoV-2 variants of concern. We also analyze the limitations of current nanomaterial approaches to managing COVID-19 and its variants alongside the challenges posed when implementing this technology. We end by providing avenues for future developments specific to disease modelling in this ever-evolving field.