AUTHOR=Lei Li , Dai Bin , Han Ting , Zhou Cheng , Gong Zhao , Zhang Ping 

TITLE=Modifying aluminum phthalocyanine with quantum dots to promote cellular uptake and enhance the efficacy of anticancer photodynamic therapy

JOURNAL=Frontiers in Materials

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/materials/articles/10.3389/fmats.2022.1056212

DOI=10.3389/fmats.2022.1056212

ISSN=2296-8016

ABSTRACT=Photodynamic therapy (PDT) is regarded as an alternative antitumor therapy which involves the
administration of photosensitizers (PSs) and the irradiation with specific light. However,
conventional PDT therapy has been limited to the efficiency of PSs delivery. Nanocarrier system
could provide an effective platform for PSs delivery and improve the efficiency of antitumor PDT
therapy. In this article, we prepared the complex consisting of aluminium phthalocyanine (AlPcS)
and CdSe/CdZnS core-shell structure QDs and investigated the interaction between the complex and
tumor cells. The more significant internalization of the conjugation was observed compared to the
free AlPcS via confocal fluorescence imaging. The tumor cells exhibited obvious apoptotic trend
after QDs-AlPcS-mediated PDT.