AUTHOR=Hilgendorff Anne , O’Reilly Michael A. 

TITLE=Bronchopulmonary Dysplasia Early Changes Leading to Long-Term Consequences

JOURNAL=Frontiers in Medicine

VOLUME=Volume 2 - 2015

YEAR=2015

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2015.00002

DOI=10.3389/fmed.2015.00002

ISSN=2296-858X

ABSTRACT=Neonatal Chronic Lung Disease, i.e. Bronchopulmonary Dysplasia (BPD) is characterized by impaired pulmonary development. Triggered by different risk factors including infections, hyperoxia and mechanical ventilation of the immature lung, remodeling of the extracellular matrix, apoptosis as well as altered growth factor signaling characterize the disease. The immediate consequences have been studied in different animal models supported by in vitro approaches leading to the successful application of these findings to the clinical setting in the past. Nonetheless, existing information about long-term consequences of the identified early and most likely sustained changes to the developing lung is limited. Interesting results point towards a tremendous impact on the pulmonary repair capacity as well as aging related processes in the adult lung.