AUTHOR=Carrillo-Linares Juan Luis , García-Fernández María Inmaculada , Morillo María José , Sánchez Purificación , Rioja José , Barón Francisco Javier , Ariza María José , Harrington Dominic J. , Card David , Boraldi Federica , Quaglino Daniela , Valdivielso Pedro 

TITLE=The Effects of Parenteral K1 Administration in Pseudoxanthoma Elasticum Patients Versus Controls. A Pilot Study

JOURNAL=Frontiers in Medicine

VOLUME=Volume 5 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00086

DOI=10.3389/fmed.2018.00086

ISSN=2296-858X

ABSTRACT=Introduction
Pseudoxanthoma elasticum (PXE) is a rare disease caused by mutations in the ABCC6 gene.   Vitamin K1 is involved in the post-translational carboxylation of some proteins related to inhibition calcification process. Our aim was to investigate whether parenteral administration of vitamin K1 is effective in modulating the levels of circulating vitamin-K-dependent proteins and metabolites in patients affected by Pseudoxanthoma elasticum.