AUTHOR=Bonnet Anne-Laure , Chaussain Catherine , Broutin Isabelle , Rochefort Gaël Y. , Schrewe Heinrich , Gaucher Céline 

TITLE=From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?

JOURNAL=Frontiers in Medicine

VOLUME=Volume 5 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00335

DOI=10.3389/fmed.2018.00335

ISSN=2296-858X

ABSTRACT=First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g. kidney, aorta, brain) postnatally. Vasn KO mice die after three weeks of life from non-known cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF- and Notch1 pathways offer the most serious assumptions regarding VASN functions. In this review, we will describe current knowledge about this glycoprotein and discuss its implication in various organ pathobiology.