AUTHOR=Tan Ying , Qin Yan , Yu Xiao-juan , Xu Rong , Wang Su-xia , Zhou Fu-de , Zhao Ming-hui 

TITLE=Case Report: Predominant Tubulointerstitial Lupus Nephritis or the Combination With IgG4-Related Disease?

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.684889

DOI=10.3389/fmed.2021.684889

ISSN=2296-858X

ABSTRACT=Isolated or dominant tubulointerstitial lupus nephritis is rare. Here we reported a 67-year-old man diagnosed with systemic lupus erythematosus (SLE) based on clinical and laboratory criteria, who was showing impaired renal function and non-nephrotic range proteinuria in the past two years. Renal biopsy showed normal glomeruli but the tubulointerstitium showed ‘storiform’ pattern with interstitial infiltration of IgG3 predominant plasma cells. The immunofluorescence showed IgG and C1q linear and granular staining along TBM and interstitium. He was started on medium dose of oral steroids and mycophenolate mofetil, which were gradually tapered. As a result, His renal function improved over a few days. Now he is continued on low dose steroids and mycophenolate mofetil with no evidence of relapse.