AUTHOR=Cousin Vladimir L. , Giraud Raphael , Bendjelid Karim 

TITLE=Pathophysiology of COVID-19: Everywhere You Look You Will See ACE2!

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.694029

DOI=10.3389/fmed.2021.694029

ISSN=2296-858X

ABSTRACT=Abstract: (99 words)
Angiotensin converting enzyme 2 (ACE2) seems to be a central actor in the pathophysiology of SARS-Cov-2 infection. First, it acts as the receptor for the virus and permits its attachment to cells expressing ACE2. Second, the relative deficiency of ACE2 during infection could be linked to several clinical features encountered during the disease, like ARDS and coagulation abnormalities. The important fact to underline is the strong link between ACE2 and the majority of risk factors for severe evolution of COVID-19, as It seems that all these risks factors are linked to an ACE2 increased level and/or imbalance in ACE/ACE2.