AUTHOR=Mohamed-Noriega Karim , Treviño-Herrera Alan B. , Mohamed-Noriega Jibran , Velasco-Sepúlveda Braulio H. , Martínez-Pacheco Víctor A. , Guevara-Villarreal Dante A. , Rodríguez-Medellín Delia L. , Sepúlveda-Salinas Anna G. , Villarreal-Méndez Gerardo , González-Cortés Jesús H. , Elizondo-Omaña Rodrigo E. , Guzmán-López Santos , Mohamed-Hamsho Jesús 

TITLE=Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.697585

DOI=10.3389/fmed.2021.697585

ISSN=2296-858X

ABSTRACT=Purpose: To assess the relationship and prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with poor final best-corrected visual acuity (BCVA) after surgical repair of open globe injuries (OGI) in adults.
Design: Retrospective analysis of data from an ongoing prospective cohort of consecutive patients.
Methods: In a tertiary university hospital, 197 eyes of 197 patients were included between 2013-2017. NLR and PLR were obtained from preoperative blood tests to analyze its relationship with poor final BCVA. 
Results: Severe visual impairment (SVI) was defined as ≤ 20/200, and was observed in 96 (48.7%) patients after surgical repair of OGI. SVI patients had higher NLR (7.4±6.6 vs 4.0±3.2, p<0.001), and PLR (167±92 vs 139±64; p=0.021) than non-SVI. NLR3.47 and PLR112.2 were the best cut-off values for SVI, were univariate risk factors for SVI, and had sensitivity: 69.0, 71.4, and specificity: 63.6, 44.8, respectively. In multivariate analysis, only OTS, athalamia, and hyphema remained as risk factors. NLR had significant correlation with ocular trauma score (OTS) (r=-0.389, p<0.001) and final BCVA (r=0.345, p<0.001). Limitations: Simultaneous trauma in other parts of the body that could influence the laboratory findings.
Conclusion: Patients with SVI after a repaired OGI had increased pre-operative NLR and PLR levels. High NLR and PLR are risk factors for SVI in univariate analysis. It is confirmed that low OTS is a risk factor for SVI. High NLR and PLR could be used as a prognostic tool to identify patients at higher risk for SVI after repair of OGI.