AUTHOR=Xu Wen , Tan Ruoming , Huang Jie , Qin Shuai , Wu Jing , Qiu Yuzhen , Xie Simin , Xu Yan , Du Ying , Li Feng , Li Bailing , Li Yingchuan , Gao Yuan , Li Xin , Qu Hongping TITLE=Case Report: Respiratory Management With a 47-Day ECMO Support for a Critical Patient With COVID-19 JOURNAL=Frontiers in Medicine VOLUME=Volume 8 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.714387 DOI=10.3389/fmed.2021.714387 ISSN=2296-858X ABSTRACT=This paper reports a complete case of severe ARDS caused by COVID-19, who presented with rapid deterioration of oxygenation during hospitalization despite escalating high-flow nasal cannulation to invasive mechanical ventilation. After inefficacy with lung-protective ventilation, PEEP titration, prone position, we administered ECMO as a salvage respiratory support with ultra-protective ventilation for 47 days and finally discharged the patient home with a good quality of life after 76 days of hospitalization. The purpose of this paper is to provide a clinical reference for the management of ECMO and respiratory strategy of critical patients with COVID-19-related ARDS.