AUTHOR=Gong Nirong , Zhou Chun , Hu Jianxia , Zhong Xiaohong , Yi Zhixiu , Zhang Tingting , Yang Cong , Lin Yanhong , Tian Jianwei , Qin Xianhui , Hu Liping , Jiang Jianping 

TITLE=High-Salt Diet Accelerated the Decline of Residual Renal Function in Patients With Peritoneal Dialysis

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.728009

DOI=10.3389/fmed.2021.728009

ISSN=2296-858X

ABSTRACT=Objective: To investigate the relationship between dietary salt-intake and residual renal function in peritoneal dialysis (PD) patients. 
Methods: The daily salt intake of the patients was calculated based on the three-day dietary records. The 62 patients were divided into three groups: 33 patients were in the low salt-intake group (salt-intake < 6.0g/day), 17 were in the medium salt-intake group (salt-intake 6.0-<8.0g/day,), and 12 were in the high salt-intake group (salt-intake ≥ 8.0g/day). Regular follow-up was conducted every 3 months. The urine volume, peritoneal ultrafiltration volume, and other clinical indicators were recorded. Biochemical indexes were detected to evaluate the changes in residual renal function and peritoneal function during follow-up. 
Results: A positive correlation between dietary sodium intake and sodium excretion was found. During 12-month’ follow-up, decrease of residual renal function showed significant difference among 3 groups (P=0.041) (15.3±27.5 vs. 12.5±11.5 vs. 32.9±18.4 L/W/1.73m2 in the low, medium, and high salt-intake group, respectively). Consistently, a higher decline of residual renal function (adjusted β, 20.37; 95%CI: 2.83, 37.91) was found in participants with high salt-intake (salt intake ≥8g/d) compared with those in non-high salt-intake.
Conclusion: Our study showed that the sodium excretion by peritoneal dialysis was positively correlated with dietary sodium intake in PD patients. The high salt-intake diet (salt intake ≥8g/d) may lead to a faster decline of residual renal function in PD patients.