AUTHOR=Li Yuancun , Guo Chengyao , Huang Chukai , Jing Liu , Huang Yingzi , Zhou Ruiqing , Qiu Kunliang , Zhang Mingzhi 

TITLE=Development and Evaluation of the Prognostic Nomogram to Predict Refractive Error in Patients With Primary Angle-Closure Glaucoma Who Underwent Cataract Surgery Combined With Goniosynechialysis

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.749903

DOI=10.3389/fmed.2021.749903

ISSN=2296-858X

ABSTRACT=Objective: To evaluate the accuracy of different intraocular lens (IOL) power calculation formulas and develop prognostic nomograms to predict the risk of postoperative refractive error in Primary Angle-Closure Glaucoma (PACG) patients. 
Methods: A total of 111 eyes with PACG underwent goniosynechialysis combined with phacoemulsification and IOL implantation were included. SRK/T, Barrett II, Hoffer Q and Kane formulas were used to predict postoperative refraction. Prediction error (PE) and absolute predictive error (APE) produced by the four formulas were calculated and compared. An APE greater than 0.50 D was defined as the event. Binary logistic regression analysis and prognostic nomogram models were conducted to investigate reliable predictors associated with postoperative refraction.
Results: The Kane (-0.06 D) and Barrett II (-0.07 D) formulas had mean prediction error close to zero (P = 0.44, P = 0.41, respectively). The Hoffer Q and SRK/T produced significantly myopic outcomes (P = 0.003, P = 0.013, respectively). The percentage of eyes within ± 0.5 D was 49.5% (55/111), 44.1% (49/111), 43.2% (48/111), 49.5% (54/111), for the Kane, Barrett II, Hoffer Q and SRK/T formula, respectively. Nomogram showed that AL had the greatest impact on the refractive outcomes, indicating a shorter preoperative AL is associated with a greater probability of refractive error event. The Area under the receiver operator curve (AUC) of the nomogram for the Kane, Barrett II, Hoffer Q and SRK/T was 0.690, 0.701, 0.708 and 0.676, respectively.
Conclusions: The Kane and Barrett II formulas were comparable and outperformed Hoffer Q and SRK/T in the total PACG eyes receiving cataract surgery combined with goniosynechialysis. The developed nomogram models can effectively predict the occurrence of postoperative refractive error events.