AUTHOR=Yu Jinguo , Hu Xingxing , Zhang Jiangkai , Han Han , Huang Bo , Brant Rodrigo , Zhang Cheng , Yan Hua TITLE=Effects of the Pars Plana Vitrectomy on the Chronic Total Rhegmatogenous Retinal Detachment in the Young Adults JOURNAL=Frontiers in Medicine VOLUME=Volume 8 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.755389 DOI=10.3389/fmed.2021.755389 ISSN=2296-858X ABSTRACT=Objectives: To observe the characteristics and evaluate the efficacy and safety of chronic total rhegmatogenous retinal detachment (RRD) treatment by 23-gauge pars planavitrectomy (PPV) in young adults and to analyze related factors. Methods: A retrospective chart review was performed for young adults who underwent 23-gauge PPV for chronic total RRD at Tianjin Medical University General Hospital from 2011 to 2018. A total of 54 eyes of 48 patients were included in this study. The preoperative vision ranged from 2.00 to 1.00. The mean duration of RRD was 9±0.6 months with a range from 4 to 18 months. Proliferative vitreoretinopathy (PVR) grade D1 and grade D2 were diagnosed in 48 eyes and 6 eyes, respectively. Thirty-seven eyes were filled with C3F8, and 17 eyes were filled with silicone oil tamponade. The follow-up ranged from 9 months to 78 months with a mean of 23±2.2 months. Results: The postoperative visual acuity increased in all eyes at the final observation. Retinal attachment was achieved in 49 eyes (90.7%) in primary PPV. Five eyes (9.3%) with failed retinal attachment finally achieved attachment after the second procedure. The postoperative complications mainly included temporary IOP elevation, hyphema, and retinal redetachment. Conclusions: Chronic total RRD can be treated via 23-gauge PPV with great anatomical and visual prognosis in young adult. The successful treatment of chronic total RRD in young adults is mainly associated with the complete dissection of severe vitreoretinopathy, especially for the epiretinal membrane at retinal breaks and degenerations, and subretinal proliferation during surgery.