AUTHOR=Kim Kyung Woo , Kusuhara Sentaro , Imai Hisanori , Sotani Noriyuki , Nishisho Ryuto , Matsumiya Wataru , Nakamura Makoto 

TITLE=Outcomes of Primary 27-Gauge Vitrectomy for 73 Consecutive Cases With Uveitis-Associated Vitreoretinal Disorders

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.755816

DOI=10.3389/fmed.2021.755816

ISSN=2296-858X

ABSTRACT=Background: Since the advent of 27-gauge microincision vitrectomy system a decade ago, evidence regarding the feasibility, safety, and effectiveness of 27-gauge pars plana vitrectomy (PPV) has increased.
Aim: To assess the effectiveness and safety profile of 27-gauge PPV for various vitreoretinal conditions associated with uveitis.
Methods: We retrospectively investigated 73 consecutive cases that underwent primary 27-gauge PPV for uveitis-related ocular disorders between October 2014 and April 2021. The primary outcome measures were mean change in logMAR best-corrected decimal visual acuity (BCVA) preoperatively to 3 months postoperatively, the proportion of BCVA improvement category defined as the degree of logMAR BCVA difference (“improved” [≤−0.3], “unchanged” [−0.3 to 0.3], and “worsened” [≥0.3]) preoperatively to 3 months postoperatively, the mean change in intraocular inflammation scores preoperatively to 3 months postoperatively; and intraoperative and postoperative complications.
Results: The mean logMAR BCVA significantly improved from 0.69 preoperatively to 0.42 at 3 months postoperatively (P = 0.017). The percentages of eyes with “improved,” “unchanged,” and “worsened” BCVA at 3 months postoperatively were 37%, 50%, and 13%, respectively. The mean anterior chamber cell score was 0.6 preoperatively and 0.2 at 3 months postoperatively (P = 0.001), the mean anterior chamber flare score was 0.4 preoperatively and 0.1 at 3 months postoperatively (P = 0.004), and the mean vitreous haze score was 1.9 preoperatively and 0.1 at 3 months postoperatively (P < 0.001). Surgery-related complications occurred in 35 (48%) eyes, 68% of which were related to intraocular pressure and transient.
Conclusions: Given its risk–benefit profile, 27-gauge PPV is a promising option for the treatment of vitreoretinal disorders in uveitis.