AUTHOR=Chen Zhangling , Xiao Ying , Qian Yu , Lin Qiurong , Xiang Zhaoyu , Cui Lipu , Sun Jiaqi , Li Sicong , Qin Xinran , Yang Chenhao , Zou Haidong 

TITLE=Incidence and Risk Factors of Dry Eye in Children and Adolescents With Diabetes Mellitus: A 3-Year Follow-Up Study

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.760006

DOI=10.3389/fmed.2021.760006

ISSN=2296-858X

ABSTRACT=Purpose: To investigate the incidence and risk factors of dry eye in diabetic children over a period of 3 years. 
Methods: Diabetic children and adolescents (age: 3–14 years) from the Shanghai Children and Adolescent Diabetes Eye (SCADE) study cohort who did not have dry eyes in January 2018 were followed-up for 3 years and re-examined in January 2021, and the incidence rate and risk factors for dry eye were calculated.
Results: Nine of 40 diabetic children and adolescents followed-up for 3 years were diagnosed with dry eye, resulting in a 3-year incidence rate of 22.5% and an annual mean incidence rate of 7.5% for dry eye. Univariate regression analysis confirmed that long duration of diabetes mellitus (odds ratio [OR] = 1.80), decreased corneal sensation (OR = 25.60), eye pain (OR = 12.27), and parental dry eye (OR = 15.99) were the risk factors for dry eye in diabetic children and adolescents.
Conclusions: The incidence of dry eye in diabetic children and adolescents is high, and corresponding measures should be taken to reduce the incidence of dry eye in the susceptible population.