AUTHOR=Fathi Ibrahim , Miki Toshio 

TITLE=Human Amniotic Epithelial Cells Secretome: Components, Bioactivity, and Challenges

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.763141

DOI=10.3389/fmed.2021.763141

ISSN=2296-858X

ABSTRACT=Human amniotic epithelial cells (hAEC) derived from placental tissue have received significant attention as a promising tool in regenerative medicine. Several studies demonstrated their anti-inflammatory, anti-fibrotic, and tissue repair potentials. These effects were further shown to be retained in the conditioned medium of hAEC, suggesting their paracrine nature. The concept of utilizing the hAEC secretome has thus evolved as a therapeutic cell-free option. In this article, we review the different components and constituents of hAEC secretome and their influence as demonstrated through experimental studies in the current literature. Studies examining the effects of conditioned medium, exosomes, miRNA derived from hAEC are included in this review. The challenges facing the application of this cell-free approach will also be discussed based on the current evidence.