AUTHOR=Cheng Yi , Zhang You , Tu Boxiang , Qin Yingyi , Cheng Xin , Qi Ran , Guo Wei , Li Dongdong , Wu Shengyong , Zhu Ronghui , Zhao Yanfang , Tang Yuanjun , Wu Cheng 

TITLE=Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.779627

DOI=10.3389/fmed.2021.779627

ISSN=2296-858X

ABSTRACT=Objective This study aimed to explore the association between base excess (BE) and the risk of 30-day mortality among patients with acute kidney injury (AKI) in the intensive care unit (ICU).
  Methods: This retrospective study included patients with AKI from the Medical Information Mart for Intensive Care (MIMIC)-IV database. We used a multivariate Cox proportional-hazards model to obtain the hazard ratio (HR) for the risk of 30-day mortality among patients with AKI. Furthermore, we utilized a Cox proportional-hazard model with restricted cubic splines (RCS) to explore the potential non-linear associations. 
  Results Among the 14,238 ICU patients with AKI, BE showed a U-shaped relationship with risk of 30-day mortality for patients with AKI, and higher or lower BE values could increase the risk. Compared with normal base excess (-3 to 3 mmol/L), patients in different groups (BE ≤ -9 mmol/L, -9 mmol/L