AUTHOR=Jiang Chengzhi , Deng Zilong , Huang Jin , Deng Haoyu , Tan Jia , Li Xinhui , Zhao Min 

TITLE=Monitoring and Predicting Treatment Response of Extraocular Muscles in Grave's Orbitopathy by 99mTc-DTPA SPECT/CT

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.791131

DOI=10.3389/fmed.2021.791131

ISSN=2296-858X

ABSTRACT=<p><bold>Objective:</bold> To investigate single-photon emission computed tomography/computed tomography (SPECT/CT) for assessing inflammation in the extraocular muscles (EOMs) and predicting the therapeutic efficacy of periocular glucocorticoid therapy (PGT) for Grave's ophthalmopathy (GO).</p><p><bold>Materials and Methods:</bold> A total of 412 eyes from 206 patients with GO referred for <sup>99m</sup>Tc-DTPA orbital SPECT/CT were enrolled. Fourteen age- and gender-matched healthy controls (28 eyes) were included. The thickness and uptake ratio (UR) of four EOMs were derived from SPECT/CT. Eighty-six eyes from patients with GO patients received PGT. Changes in SPECT/CT parameters were evaluated between the pre- and post-treatment.</p><p><bold>Results:</bold> 195 eyes and 217 eyes were classified as active and inactive stages by clinical activity score (CAS). Values of the thickness and UR of each EOM, T<sub>max</sub>, and U<sub>max</sub> were all significantly higher in the active GO than in the inactive GO and controls (<italic>p</italic> &lt; 0.01). Among the 86 eyes (48 GO patients) included in the efficacy analysis, 56 eyes and 30 eyes were classified as responders and non-responders. Values of thicknesses and UR of each EOM, the maximum thickness (T<sub>max</sub>), and the maximum UR (U<sub>max</sub>) all dropped following PGT in the responders (<italic>p</italic> &lt; 0.01). Logistic regression analysis identified the U<sub>max</sub> as an independent predictor for the responders (<italic>p</italic> &lt; 0.01). Moreover, the U<sub>max</sub> demonstrated incremental predictive value over clinical characters and CAS, as evidenced by the improved area under the curve (0.85 vs. 0.78) and global chi-square (34.12 vs. 18.1).</p><p><bold>Conclusion:</bold><sup>99m</sup>Tc-DTPA SPECT/CT has the potential to assess inflammatory activity by detecting the involvement of EOMs in GO. Pre-treatment UR provides independent and incremental values for the prediction of PGT treatment response.</p>