AUTHOR=Nguyen Thi H. O. , Cohen Carolyn A. , Rowntree Louise C. , Bull Maireid B. , Hachim Asmaa , Kedzierska Katherine , Valkenburg Sophie A. 

TITLE=T Cells Targeting SARS-CoV-2: By Infection, Vaccination, and Against Future Variants

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.793102

DOI=10.3389/fmed.2021.793102

ISSN=2296-858X

ABSTRACT=T cells responses are a key cornerstone to viral immunity to drive high quality antibody responses, establishing memory for recall and for viral clearance. Inefficient recruitment of T cell responses plays a role in the development of severe COVID-19, and is also represented by reduced cellular responses in males, children and diversity compared to other epitope specific subsets and available T cell receptor diversity. SARS-CoV-2-specific T cell responses are elicited by multiple vaccine formats, and augmented by prior infection for hybrid immunity. Epitope conservation is relatively well maintained leading to T cell cross-reactivity for variants of concern that have diminished serological responses.