AUTHOR=Gao Chang , Guo Jiao , Gong Ting-Ting , Lv Jia-Le , Li Xin-Yu , Liu Fang-Hua , Zhang Meng , Shan Yi-Tong , Zhao Yu-Hong , Wu Qi-Jun 

TITLE=Sleep Duration/Quality With Health Outcomes: An Umbrella Review of Meta-Analyses of Prospective Studies

JOURNAL=Frontiers in Medicine

VOLUME=Volume 8 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.813943

DOI=10.3389/fmed.2021.813943

ISSN=2296-858X

ABSTRACT=Background: To quantitatively evaluate the evidence of duration and quality of sleep as measured by multiple health outcomes.
Methods: This review is registered with PROSPERO, number CRD42021235587. We systematically searched three databases from inception until November 15, 2020. For each meta-analysis, the summary effect size using fixed and random effects models, the 95% confidence interval, and the 95% prediction interval were assessed; Heterogeneity, evidence of small-study effect, and excess significance bias were also estimated. According to the above metrics, we evaluated the credibility of each association.
Results: A total of 85 meta-analyses with 36 health outcomes were included in the study. We observed highly suggestive evidence for association between long sleep and increased risk of all-cause mortality. Moreover, suggestive evidence supported the associations between long sleep and 5 increased risk of health outcomes (stroke, dyslipidaemia, mortality of coronary heart disease, stroke mortality, and the developing or dying of stroke); short sleep and increased risk of overweight and/or obesity; poor sleep quality and increased risk of diabetes mellitus and gestational diabetes mellitus.
Conclusions: Only the evidence of the association of long sleep with increased risk of all-cause mortality were graded as highly suggestive. Additional studies are needed to be conducted.