AUTHOR=Jing Yajun , Yuan Zhiyong , Zhou Weigui , Han Xiaoning , Qi Qi , Song Kai , Xing Jinyan 

TITLE=A phased intervention bundle to decrease the mortality of patients with extracorporeal membrane oxygenation in intensive care unit

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1005162

DOI=10.3389/fmed.2022.1005162

ISSN=2296-858X

ABSTRACT=Aim: To evaluate whether a phased multidimensional intervention bundle would decrease the mortality of patients with ECMO and the complication incidence. 
Methods: We conducted a prospective observational study in comparison with a retrospective control group in six ICUs in China. Patients older than 18 years supported with ECMO between March 2018 to March 2022 were included in the study. A phased intervention bundle to improve the outcome of patients with ECMO was developed and implemented. Multivariable logistic regression modeling was used to compare mortality of patients with ECMO and the complication incidence before, during, and up to 18 months after implementation of the intervention bundle. 
Results: The cohort included 297 patients in 6 ICUs, mostly VA ECMO (68.7%) with a median (25th–75th percentile) duration in ECMO of 9.0 (4.0-15.0) days. The mean (SD) APECHII score was 24.1(7.5). Overall, the mortality of ECMO decreased from 57.1% at baseline to 21.8% at 13- 18 months after implementation of the study 
intervention (P<0.001). In multivariable analysis, even after excluding the confounding factors, such an age, APECHII score, pre-ECMO lactate and incidence of CRRT during ECMO, the intervention bundle still can decrease the mortality independently, which also remained true in the statistic analysis of V-V and V-A ECMO separately. Among all the ECMO-related complications, the incidence of bloodstream infection and bleeding decreased significantly at 13-18 months after implementation compared with the baseline. The CUSUM analysis revealed a typical learning curve with a point of inflection during the implementation of the bundle.