AUTHOR=Chen Yijing , Mao Jianbo , Xiang Ziyi , Zhang Zhengxi , Zhang Shian , Wu Sulan , Shen Lijun 

TITLE=Retinal microvasculature observations of fellow eyes after intra-arterial chemotherapy for unilateral retinoblastoma using optical coherence tomography angiography

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1015301

DOI=10.3389/fmed.2022.1015301

ISSN=2296-858X

ABSTRACT=Purpose: To investigate the characteristics of the retinal microvasculature of the fellow eyes in patients with unilateral retinoblastoma (RB) after intra-arterial chemotherapy (IAC) through optical coherence tomography angiography.
Methods: This retrospective study enrolled 11 fellow eyes of patients with unilateral RB receiving IAC (group I), 9 fellow eyes of patients with unilateral RB receiving IAC and intravenous chemotherapy (IVC) (group II), and 14 age-matched normal eyes (control group). Optical coherence tomography angiography was performed on all individuals. Vascular density of superficial capillary plexus and deep capillary plexus, foveal avascular zone related parameters, and retinal thickness were measured and compared among the three groups.
Results: There was no statistical difference in age and logMAR visual acuity among the three groups. Compared with the control group, the vascular density of the deep capillary plexus was lower in group I and II. Decreased vascular density of FD-300 and thinner thickness of OPL-BRM were detected in group II compared with the control group. The vascular density and retinal thickness showed no differences between group I and II.
Conclusion: The decreased vascular density in the deep capillary plexus without measurable visual impairment was observed in fellow eyes after IAC or IAC+IVC for unilateral RB. Further studies with a larger sample would be necessary to determine the clinical significance of these findings.