AUTHOR=She Xiangjun , Zhou Congying , Liang Zhi , Xie Jin , Zhao Shixin , Tao Jiwei , Zhang Yun , Mao Jianbo , Chen Yiqi , Shen Lijun 

TITLE=Hypodense regions in the peripapillary region increased the risk of macular retinoschisis detected by optical coherence tomography

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1018580

DOI=10.3389/fmed.2022.1018580

ISSN=2296-858X

ABSTRACT=Purpose: To investigate the clinical features of peripapillary regions in patients with myopic macular retinoschisis and its association with development of retinoschisis (MRS).
Methods: Cross sectional study, highly myopic patients with or without MRS were recruited in the study, hypodense regions were analyzed in the peripapillary regions. The vitreoretinal adhesions around macular, paravascular were compared between groups. The risk factors for development of MRS was analyzed by regression. 
Results: Of 88 myopic eyes, MRS was detected in 45 eyes (51%), The eyes with MRS showed a higher rate of peripapillary retinoschisis and paravascular retinoschisis (P < 0.001, P = 0.006). Hypodense regions were detected in 25 eyes (20.35%). Higher rate of horizontal and vertical macular MRS were detected in hypodense group (P=0.012, P = 0.002). Lower refractive error, longer axial length, higher rates of outer retinoschisis both in horizontal and vertical macular were observed in hypodense group(P = 0.012, P = 0.006, P = 0.038, P = 0.034). Higher rates of inner, outer retinoschisis, vitreoschisis and microfolds along superior vascular arcade were detected in hypodense group (P = 0.005, P = 0.001, P = 0.014, P=0.014). Higher rates of ILM detachment, inner RS, outer RS were detected along inferior vascular arcade in hypodense group (P=0.008, P=0.001, P=0.028). Hypodense regions, axial length and PICC were significantly correlated with severity of macular retinoschisis 
Conclusions: The hypodense regions were likely to effect outer retinoschisis both in macular and paravascular regions. It was a risk factor for development of MRS.