AUTHOR=Meng Dandan , Zhu Chengfeng , Jia Ruixue , Li Zongxin , Wang Wantao , Song Suhua 

TITLE=The molecular mechanism of ferroptosis and its role in COPD

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1052540

DOI=10.3389/fmed.2022.1052540

ISSN=2296-858X

ABSTRACT=Abstract: As a new type of cell death, ferroptosis is mainly characterized by intracellular iron accumulation and lipid peroxidation. The complex regulatory network of iron metabolism, lipid metabolism, amino acid metabolism and P53, Nrf2-related signaling factors are involved in the whole process of ferroptosis.It has been reported that ferroptosis is involved in the pathogenesis of neurological diseases, cancer, and ischemia-reperfusion injury.Recent studies have found that ferroptosis is closely related to the pathogenesis of COPD, which to some extent indicates that ferroptosis is a potential therapeutic target for COPD.This article mainly discusses the related mechanisms of ferroptosis, including metabolic regulation and signaling pathway regulation, with special attention to its role in the pathogenesis of COPD, aiming to provide safe and effective therapeutic targets for chronic airway inflammatory diseases.