AUTHOR=Scholl Sarah , Schuster Daniel , Technau-Hafsi Kristin , Stete Katarina , Rieg Siegbert , May Annette M. , Bogdan Christian , Schauer Franziska 

TITLE=Case report: Cutaneous pseudolymphoma caused by a Leishmania infantum infection in a patient treated with anti-TNF antibody for plaque psoriasis

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1055703

DOI=10.3389/fmed.2022.1055703

ISSN=2296-858X

ABSTRACT=Adalimumab is approved for the treatment of psoriasis, which affects up to 2% of the population. Here, we present a middle-aged Italian man with long-term history of plaque psoriasis and psoriasis arthropathica. During the therapy with methotrexate and adulimumab he developed nodules and ulcers within the psoriatic plaques that were found to be positive for Leishmania infantum. After discontinuation of the anti-TNF-treatment, the infection resolved without anti-leishmanial therapy, which underlines the critical role of TNF for parasite control.