AUTHOR=Amrane Karim , Le Meur Coline , Thuillier Philippe , Alemany Pierre , Niel Clémence , Renault David , Abgral Ronan 

TITLE=Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on 18F-FDG-PET/CT

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1078560

DOI=10.3389/fmed.2022.1078560

ISSN=2296-858X

ABSTRACT=Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. Here, the authors present a very rare case of immune checkpoint inhibitors (ICI) induced EF revealed by 18F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after initiation of Pembrolizumab treatment of a relapsed non-small cell lung cancer (NSCLC). It concerned a 52-year-old Caucasian woman clinically presenting asthenia, inflammatory muscle and joint pain associated with subcutaneous nodules and symmetrical edema of the lower limbs. Iterative 18FDG-PET/CT scans allow to guide the therapeutic strategy due to this atypical ICI adverse event.