AUTHOR=Calvino-Suarez Cristina , Ferreiro-Iglesias Rocío , Baston Rey Iria , Barreiro-de Acosta Manuel 

TITLE=Managing ulcerative colitis after surgery

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1081940

DOI=10.3389/fmed.2022.1081940

ISSN=2296-858X

ABSTRACT=Management of ulcerative colitis after surgery suggested by guidelines (total proctocolectomy with ileal-pouch anal anastomosis) is a big challenge for physicians, because patients who believed that their disease had been cured, started again with very uncomfortable symptoms. A high number of patients develop episodes of pouchitis, which is a non-specific inflammation of the pouch, whose aetiology is unknown. Anibiotics are the elective treatment for acute pouchitis, but more often than is expected evolves into chronic pouchitis. This condition is very complicated to treat, due to absence of well-designed specific studies for this group of patients. Antibiotics, budesonide and biological therapies are some of the recommended drugs for these patients, but despite of their use, some need permanent ileostomy.