AUTHOR=Gebetsberger Jennifer , Schirmer Michael , Wurzer Walter J. , Streif Werner 

TITLE=Low Bone Mineral Density in Hemophiliacs

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.794456

DOI=10.3389/fmed.2022.794456

ISSN=2296-858X

ABSTRACT=Objective: To review the current knowledge on bone health in patients with hemophilia A and the underlying pathogenetic mechanisms.
Data sources: Original research articles, meta-analyses, and scientific reviews.
Data synthesis: Already in childhood, patients with hemophilia A are prone to low bone mineral density, leading to osteopenia and/or osteoporosis. Initially associated with the life style of hemophilia, today we are faced with accumulating evidence that coagulation factor VIII is involved directly or indirectly in bone physiology.
Conclusion: Understanding the role of factor VIII and the mechanisms of decreased bone mineral density in hemophilia A is critically important, especially as non-factor replacement therapies are available, and treatment decisions potentially impact bone health.