AUTHOR=Yang Qilin , Gao Jun , Zeng Xiaomei , Chen Junyu , Wen Deliang 

TITLE=Relationship Between Platelet Count and In-hospital Mortality in Adult Patients With COVID-19: A Retrospective Cohort Study

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.802412

DOI=10.3389/fmed.2022.802412

ISSN=2296-858X

ABSTRACT=Background:Thecoronavirus disease 2019 (COVID-19) has become a global pandemic.Systemic inflammation in COVID-19 patients has been associated with poor clinical outcome.This study aims to determine the relationship between platelet count and in-hospital mortality.Methods: In this respective cohort study, we adopted multi-variable logistic regression analyses and smooth curve fitting to assess the independent association between platelet count and in-hospital mortality. We further applied a two-piecewise linear regression model examine the nonlinearassociation between platelet count and in-hospital mortality. Results: Of the 2006 patients, the average age of the participants was65.9±16.5 years and 42.6% were female. We observed a U-shaperelationship between platelet count and in-hospital mortality. We found two different slopes,the correlations between platelet count and in-hospital mortality of COVID-19 patients were totally different below and above the inflection point which was around 370× 109/L. On the left side of inflection point, the OR was 0.996(OR:0.996,95%CI:0.994~0.998, p< 0.001). On the right side of inflection point, the OR was 1.011 (OR:1.011,95%CI:1.001~1.021, p=0.029). Conclusions:A U-shape association between platelet count and in-hospital mortality was found in the patients with COVID-19. The optimal of platelet count associated with the lowest risk of in-hospital mortality was around 370× 109/L.