AUTHOR=Ou Shuo-Ming , Lee Kuo-Hua , Tsai Ming-Tsun , Tseng Wei-Cheng , Chu Yuan-Chia , Tarng Der-Cherng 

TITLE=Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.809292

DOI=10.3389/fmed.2022.809292

ISSN=2296-858X

ABSTRACT=Background: Sepsis is known to cause renal function fluctuations during hospitalization, but whether these patients discharged from sepsis were still at greater risks of long-term renal adverse outcomes remains unknown.
Methods: From 2011 to 2018, we included 112,628 chronic kidney disease (CKD) patients aged ≥ 20 years. The CKD patients were further divided into 11,661 sepsis group and 100,967 nonsepsis group. The following outcome of interests were included: all-cause mortality, readmission for acute kidney injury (AKI), eGFR decline ≥ 50% or doubling of serum creatinine and end-stage renal disease (ESRD).
Results: After propensity score matching, the sepsis group was at higher risks of all-cause mortality (hazard ratio [HR] 1.39, 95% confidence interval [95% CI], 1.31 to 1.47), readmission for acute kidney injury (HR 1.67, 95% CI 1.58 to 1.76), eGFR decline ≥ 50% or doubling of serum creatinine (HR 3.34, 95% CI 2.78 to 4.01) and end-stage renal disease (HR 1.43, 95% CI 1.34 to 1.53) than nonsepsis group. 
Conclusions: Our study found that CKD patients discharged from hospitalization for sepsis have higher risks of subsequent renal adverse events.