AUTHOR=Kang Youra , Park Hyeonjeong , Choe Byung-Ho , Kang Ben 

TITLE=The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.848344

DOI=10.3389/fmed.2022.848344

ISSN=2296-858X

ABSTRACT=The mucus layer is an essential component of the human intestinal barrier since it protects the barrier, regulates intestinal microbiome homeostasis, and prevents disease. Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as a major component of mucus. In this review, we summarize MUC2 mucin features and its role in intestinal disease. Furthermore, we examined whether the role of MUC2 mucin differed between children and adults, and ulcerative colitis (UC) and Crohn’s disease (CD).