AUTHOR=Singh Vimal Kishor , Sharma Pallavi , Vaksh Uttkarsh Kumar Sharma , Chandra Ramesh 

TITLE=Current approaches for the regeneration and reconstruction of ocular surface in dry eye

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.885780

DOI=10.3389/fmed.2022.885780

ISSN=2296-858X

ABSTRACT=Significant research revealed the preocular tear film composition and regulations that remain vital for the maintenance of Ocular surface functional integrity. Inflammation triggered by many factors is the hallmark of Ocular surface disorders or dry eyes syndrome (DES). The tear deficiencies may lead to ocular surface desiccation, corneal ulceration and/or perforation, higher rates of infectious disease, as well as the risk of severe visual impairment and blindness. Clinical management remains largely supportive, and palliative and a frequent, lifelong use of different lubricating agents. Few advancements such as punctual plugs, non-steroidal anti-inflammatory drugs, salivary gland autograft are of limited use. Recently, cell-based therapies, tissue engineering, and regenerative medicine have evolved as a long-term cure for many diseases including ophthalmic diseases. The present article focuses on the different regenerative medicine and reconstruction/ bioengineered lacrimal gland formation strategies reported so far along with their limiting factors and feasibility as an effective cure in the future.