AUTHOR=Cheng Linyan , Wang Yi , Lu Hanzhi , Guo Wanjun , Yan Ge , Zhu Jianyong , Guo Dongjie , Li Fulun 

TITLE=Successful Treatment of Bullous Pemphigoid Lesions by Berberine Stamp Therapy: A Case Report and Literature Review

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.938761

DOI=10.3389/fmed.2022.938761

ISSN=2296-858X

ABSTRACT=Bullous pemphigoid (BP) is a life-threatening autoimmune disease of the skin, which is mainly characterized by large areas of tonic blisters and intense itching of the skin. The one-year mortality rate of BP was 23.5%. Superinfection caused by skin lesion ulceration is one of the important causes of disease death. Therefore, it is a challenge to control infection and improve skin wound healing. Here, we report the case of an elderly woman who presented with BP and involved the oral mucosa. The patient was successfully treated with hormones combined with topical berberine and 95% of the patients' lesions healed completely after one month. In addition, we inductively analyzed the current treatments for BP, so as to provide a reference for the clinical treatment of BP.