AUTHOR=Sun XiaoHan , Ni Hong Bo , Xue Jian , Wang Shuai , Aljbri Afaf , Wang Liuchun , Ren Tian Hang , Li Xiao , Niu Meng 

TITLE=Bibliometric-analysis visualization and review of non-invasive methods for monitoring and managing the portal hypertension

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.960316

DOI=10.3389/fmed.2022.960316

ISSN=2296-858X

ABSTRACT=Abstract
Background: Portal hypertension monitoring, the efficacy indicator and prognostic factor of the related therapies, is important throughout the natural course of cirrhosis. Hepatic venous pressure gradient (HVPG), regarded as golden standard, limited by its invasiveness and technical difficulties. A growing number of studies have focused on the non-invasive assessment of portal hypertension, hematological indices, imaging data and statistical or computational models was studied to surrogate HVPG. First, the paper will use VOSviewer to learn the architecture of this field. Further details about the principles, pros and cons, and applicable scenarios will follow.
Method: The publications about the noninvasive assessment of portal hypertension were retrieved from the Web of Science Core Collection (WoSCC). VOSviewer 1.6.17.0 was used to analyze and visualize these publications, including the annual trend, the study hotspots, the significant articles, authors, journals and organizations in this field.
Results: 1088 articles or review articles about our topic were retrieved from WoSCC. From 2000 to 2022, the number of publications is generally growing. “World Journal of Gastroenterology” published the most articles (n=43), while “Journal of Hepatology” had the highest citations. “Liver fibrosis” published in 2005 was the most influential manuscripts. In total 20558 references were cited by the 1088 retrieved manuscripts, a study about liver stiffness measurement published in 2007 was the highest-cited. The highest-yielding country was the USA, followed by China and Italy. “Berzigotti, Annalisa” was the most prolific author and have the most cooperation partners. According to the keywords clustering, there are four study directions: (1) the evaluation based on fibrosis; (2) the evaluation based on hemodynamic factors; (3) the evaluation through elastography; (4) the evaluation of variceal bleeding.
Conclusion: The noninvasive assessment of portal hypertension is mainly based on two principles: fibrosis and hemodynamics. Liver fibrosis was the major initiator and mainly explained the intrahepatic part of portal hypertension. While hemodynamic factors could divide into intrahepatic perfusion and extrahepatic blood flow. Blood tests, US (including DUS and CEUS), CT and MRI supported the noninvasive assessment of PH by providing both hemodynamic and fibrotic information. Elastography, mainly USE was the most important method of PH monitoring.