AUTHOR=Zhou Yun , Zhong Lixian , Shen Lianli , Chen Sisi , Zeng Qiuting , Lai Leizhen , Tang Shaohui 

TITLE=Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses

JOURNAL=Frontiers in Medicine

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.998815

DOI=10.3389/fmed.2022.998815

ISSN=2296-858X

ABSTRACT=Purpose: Based on the large number of systematic review and meta-analyses exploring
the relationship between psoriasis and various health outcomes, we conducted an
umbrella review to assess the strength and evidence for the association between
psoriasis and medical end-point ramifications in patients.
Methods: We searched related meta-analyses that investigating the links between
psoriasis and medical ramifications from three databases. All summary effect sizes,
95%CIs, heterogeneity and small-study effects in the included meta-analyses were
recalculated. We assessed the methodological quality of included articles with
AMSTAR 2 tool and graded the epidemiologic evidence. Subgroup analysis based on
the severity of psoriasis and study design were also performed.
Results: A total of 38 articles comprising 85 unique meta-analyses were included in
this study. Although 69 outcomes were statistically significant, only 8 outcomes (non-
vascular dementia, ulcerative colitis, pediatric dyslipidemia, gestational diabetes,
gestational hypertension, fracture, multiple sclerosis, schizophrenia) showed high
quality of epidemiological evidence.
Conclusion: We found that psoriasis increased the risk of 69 health outcomes and 8
outcomes were graded as high quality of evidence. No evidence was found that
psoriasis was beneficial for any medical end-point. However, in order to verify our
results, more large-sample, muti-center prospective cohort studies are needed.