AUTHOR=Luo Jiao , Liu Cheng , Lv Qing-Jian , He Ting , Qiang Xing , Li Yi , Huang Qi-Mi , He Jia-Lin 

TITLE=Non-hepatitis-associated mixed cryoglobulinemia with polyclonal plasma cells disease and alcoholic cirrhosis: A rare case report

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1014261

DOI=10.3389/fmed.2023.1014261

ISSN=2296-858X

ABSTRACT=Mixed cryoglobulinemia refers to the serum presence of a variety of cryoglobulins, which are defined as immunoglobulins that precipitate at temperatures <37°C. The most common cause of mixed cryoglobulinemia is hepatitis C virus (HCV), while other infections including hepatitis B virus (HBV) and HIV infections, lymphoproliferative and autoimmune disorders have also been associated with the disease. We reported a rare case of type II-III mixed cryoglobulinemia caused by alcoholic cirrhosis. We need to increase the awareness of and facilitate the earlier identification of mixed cryoglobulinemia in our clinical work, when encountering a patient with liver cirrhosis combined with renal impairment so that treatment can begin early, to improve the success rate of therapy and reduce the fatality rate in potentially life-saving therapy.