AUTHOR=Pan Peng , Gu Lun , Zhao Shengbing , Wang Shuling , Ma Jiayi , Fu Hongyu , Chen Youxiang , He Shuixiang , Tian Zibin , Xu Le , Feng Zhijie , Li Yanqing , Yang Zhuo , Yang Lei , Wang Wen , Hou Qian , Liu Ting , Li Chujun , Tian Dean , Wang Xiaodi , Gao Yongmei , Shi Hanping , Bai Yu , Li Zhaoshen 

TITLE=Prepackaged formula low-residue diet vs. self-prepared low-residue diet before colonoscopy: A multicenter randomized controlled trial

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1029493

DOI=10.3389/fmed.2023.1029493

ISSN=2296-858X

ABSTRACT=Background and Aims: Compared with self-prepared LRD, prepackaged low-residue diet (LRD) can improve patient compliance, but whether it can further improve the quality of bowel preparation is uncertain.The study aimed to compare the application of the prepackaged formula LRD with self-prepared LRD in bowel preparation for colonoscopy.
Methods: A multicenter randomized controlled trial was conducted in fifteen centers. The eligible subjects were randomly assigned to one of two groups: the formula LRD group and the self-prepared LRD group. On the day before colonoscopy, subjects in the self-prepared LRD group were instructed to consume a restricted LRD prepared by themselves, while subjects in the formula LRD group were given 6 bags prepackaged formula LRD and instructed to consume them according to individual need. The primary outcome was adequate bowel preparation rate. Secondly outcomes mainly included Boston Bowel Preparation Scale (BBPS) scores, dietary restriction compliance rate, tolerance, satisfaction, adenoma detection rate (ADR), and adverse reactions. The trial was registered at ClinicalTrials.gov under identifier NCT03943758.
Results: A total of 550 subjects were recruited. Compared with self-prepared LRD group, the formula LRD group showed higher adequate bowel preparation rate (94.5% vs. 80.4%; P < 0.01), BBPS scores (7.87 ± 1.13 vs. 6.75 ± 1.47; P < 0.01), dietary compliance rate (92.4% vs. 78.9%; P < 0.01), tolerance (P < 0.01 in degree of hunger, intensity of physical strength, and negative influence on daily activities), satisfaction (8.56 ± 1.61 vs. 7.20 ± 2.02; P < 0.01), and ADR (25.6% vs. 16.0%; P < 0.01). There was no significant difference in adverse reactions.
Conclusions: Compared with self-prepared LRD, the formula LRD showed similar safety and higher bowel preparation quality, compliance, and tolerance in bowel preparation. More formula LRDs could be designed according to different dietary habits, and further researches with different dietary habits and ethnic populations are warranted to confirm these results.