AUTHOR=Li Maojuan , Tao Yan , Sun Yang , Wu Jing , Zhang Fengrui , Wen Yunling , Gong Min , Yan Jingxian , Liang Hao , Bai Xinyu , Niu Junkun , Miao Yinglei 

TITLE=Constructing a prediction model of inflammatory bowel disease recurrence based on factors affecting the quality of life

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1041505

DOI=10.3389/fmed.2023.1041505

ISSN=2296-858X

ABSTRACT=Aim 
To determine the factors affecting quality of life in patients with inflammatory bowel disease (IBD) and to construct a disease recurrence prediction model based on these influencing factors.
Methods
A prospective single-center study from China was conducted between October 2020 to March 2021. Patients’ quality of life was assessed with inflammatory bowel disease questionnaire (IBDQ). Multiple stepwise regression analysis was used to analyse the factors influencing quality of life in patients with IBD. The chi-square test and point-biserial correlation analysis were performed to identify factors associated with clinical recurrence. A binary logistic regression model was constructed for the prediction of recurrence. The receiver operating characteristic curve was used to evaluate the prediction model. Patients with IBD from April 2021 to June 2021 were randomly included for model verification to evaluate the disease recurrence prediction model.
Results
The average IBDQ scores of patients with IBD was 172.2 ± 35.0 (decreased by 23.2%). The scores of all dimensions of the IBDQ were decreased, especially in emotional function and systemic symptoms. Disease activity, age, extraintestinal manifestations (EIMs), and annual household income were important factors influencing IBDQ scores of patients with ulcerative colitis, and they made up approximately 57.0% of the factors affecting the quality of life. Disease activity, EIMs, and occupational stress were important factors influencing IBDQ scores of patients with Crohn’s disease, and they made up approximately 75.1% of the factors affecting the quality of life. Annual household income, occupational stress, and IBDQ scores were independent risk factors for recurrence. The area under the curve of the recurrence prediction model was 81.1%. The sensitivity and specificity were 81.7% and 71.7% respectively. The Youden index of the model was 0.534. The established recurrence prediction model has good discriminant validity in the validation cohort.
Conclusion
The quality of life in patients with IBD was generally reduced. The use of factors affecting the quality of life to predict disease recurrence has high predictive value, and can support the management of IBD with selecting patients in higher risk for relapse.