AUTHOR=Chen XiaoLi , Xu Yan , Hu Li , Chen AiJun 

TITLE=Clinical observation and study of local hyperthermia for treating plantar warts: A pilot study with 38 patients

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1087659

DOI=10.3389/fmed.2023.1087659

ISSN=2296-858X

ABSTRACT=warts are benign lesions caused by infection of the keratinocytes by the Human Papilloma Virus (HPV). There is still no consensus on the standard treatment of plantar warts and the various treatments (both destructive and non-destructive) have variable efficacy with a string of shortcomings such as higher recurrence, pain, and scarring. Local hyperthermia was considered as a safe, effective, and promising therapy in the treatment of plantar wart in previous study. After getting approval from the hospital's Ethics Committee, the present study was designed to access the clinical efficacy for local hyperthermia in the treatment of plantar warts. Nineteen patients were enrolled in the study and all patients received a standard regimen in a 5-weekly schedule, with local 45℃ treatment for 30 minutes on days 1, 2, 3, 14, 15, 22, 29, and 36, respectively. Of the 38 patients, complete resolution of the warts was observed in 13 patients (34.2%), 8 patients (21.1%) achieved partial remission, and 17 patients (44.7%) showed poor response to treatment. Patients were followed up for at least 3 months duration, and no recurrence of lesion in 13 clinically cured patients was observed in the last follow-up. The finding in the current study demonstrated that local hyperthermia was a safe, effective, and promising therapy in the treatment of plantar wart.