AUTHOR=Ling Ma , Huiyin Li , Shanglin Chen , Haiming Li , Zhanyi Di , Shuchun Wang , Meng Bai , Murong Lu 

TITLE=Relationship between human serum albumin and in-hospital mortality in critical care patients with chronic obstructive pulmonary disease

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1109910

DOI=10.3389/fmed.2023.1109910

ISSN=2296-858X

ABSTRACT=ABSTRACT: BACKGROUND: The relationship between human serum albumin levels and the prognosis of critical care patients with chronic obstructive pulmonary disease (COPD) remains controversial. OBJECTIVE: To investigate the relationship between serum albumin levels and in-hospital mortality in critical care patients with COPD. METHODS: This study used a retrospective observational cohort from the Medical Information in Intensive Care database (MIMIC-IV) in the United States. Multivariate Cox regression analysis was used to assess the relationship between serum albumin levels and in-hospital mortality. A restricted cubic spline line was also used to explore nonlinear relationship. RESULTS: A total of 3398 critical care patients with COPD were included. The overall in-hospital mortality was 12.4%. We found a negative relationship between human serum albumin and in-hospital mortality (HR = 0.97, 95% CI 0.96-0.99, P= 0.002).  CONCLUSION: In critical care patients with COPD, there was a negative association between human serum albumin and in-hospital mortality.