AUTHOR=Litwiniuk-Kosmala Małgorzata , Makuszewska Maria , Czesak Małgorzata 

TITLE=Endoglin in head and neck neoplasms

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1115212

DOI=10.3389/fmed.2023.1115212

ISSN=2296-858X

ABSTRACT=Tumours of the head and neck region form a heterogenous group of pathologies, including various benign lesions and malignant neoplasms. Endoglin, also known as CD105, is an accessory receptor for transforming growth factor beta (TGF-β), that regulates angiogenesis, both in physiological as well as pathological conditions. It is highly expressed in proliferating endothelial cells; therefore it is considered as a marker for tumour-related angiogenesis. In this review we discuss the role of endoglin as a possible marker of tumorigenesis, as well as a potential target for antibody-based therapies in neoplasms of the head neck region.