AUTHOR=Yang Tiantian , Zhang Yang , Chen Junhang , Sun Longhao 

TITLE=Crosstalk between autophagy and immune cell infiltration in the tumor microenvironment

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1125692

DOI=10.3389/fmed.2023.1125692

ISSN=2296-858X

ABSTRACT=Autophagy is a conserved process for self-degradation and provides cells with a rescue mechanism to respond to stress or starvation. The role of autophagy in cancer is extremely complex and often paradoxical. Most published related studies in tumor are always focused on cancer cells. However, present investigations have gradually noticed the significance of autophagy in the tumor microenvironment. These studies demonstrate that autophagy and immunity work synergistically to affect tumor progression, indicating that autophagy could become a potential target for cancer immunotherapies. Therefore, it is crucial to clear the correlation between autophagy and various tumor infiltrating immune cells in the tumor microenvironment. The context-dependent role of autophagy is critical in design of therapeutic strategies for cancer.