AUTHOR=Guo Dan , Dai Jiazhen , Ju Rong , Zhou Qifan , Wang Nenghuan , Wu Chunhua , Tao Hui , Jing Hui , Zhu Chen , Mao Jinxian , Xu Jiayan 

TITLE=The relationship between triglyceride, cholesterol and lipoprotein levels, and immune responses to hepatitis B vaccine

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1131373

DOI=10.3389/fmed.2023.1131373

ISSN=2296-858X

ABSTRACT=Cholesterol homeostasis disorder and hypertriglyceridemia, as common metabolic 23
conditions, have rarely been reported to affect the immune responses to the hepatitis B vaccine. 24
Our study found that higher high-density lipoprotein (HDL)level showed a significant relationship 25
with positive anti-HBs results (cOR = 1.479, 95% CI: 1.150, 1.901, P= 0.002; aOR = 1.304, 95% CI: 26
1.006, 1.691, P = 0.045), especially in individuals aged 18- to 40-year-old, female, smoking more 27
than 100 cigarettes in life, and drinking more than 12 times every year. Lower low-density 28
lipoprotein (LDL) level was associated with a negative anti-HBs result among participants aged 29
18- to 40-year-old, and participants who were obese.Higher level of HDL and lower level of LDL 30
may be protective factors of better immune effect of hepatitis B vaccine. More research should 31
be conducted to investigate the influence of the cholesterol level on the immune responses to 32
the hepatitis B vaccine, and more in-depth research should be performed to uncover the 33
mechanism.