AUTHOR=Ardiles Leopoldo G. 

TITLE=Obesity and renal disease: Benefits of bariatric surgery

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1134644

DOI=10.3389/fmed.2023.1134644

ISSN=2296-858X

ABSTRACT=The prevalence of obesity, a preventable and reversible condition with high impact on health, continues to rise, especially after the covid-19 pandemic. Severe overweight is well recognized as a risk factor of diabetes and hypertension, among other conditions that may increase the cardiovascular risk. Obesity has also grown in parallel with the rise in the prevalence of chronic kidney disease and a pathophysiological link has been established, that explains its role in generate the conditions to facilitate the emergence and maximize the impact of the risk factors of CKD and its progression to more advanced stages.
Knowing the mechanisms involved and having different tools to reverse the overweight and its consequences, bariatric surgery has arisen as a useful and efficient method, complementary or alternative to others, like lifestyle changes and/or pharmacotherapy.
In a detailed review, the mechanisms involved in the renal consequences of obesity, the impact on risk factors and the potential benefit of bariatric surgery at different stages of disease and on its progression are exposed and analysed.
Although the observational evidence supports the value of bariatric surgery as a renoprotective measure in obese individuals, diabetic or not, randomized studies are expected, to establish evidence-based recommendations that demonstrate its positive risk-benefit balance as a complementary or alternative therapeutic tool.