AUTHOR=Almusalami Eman M. , Lockett Anthony , Ferro Albert , Posner John TITLE=Serum amyloid A—A potential therapeutic target for hyper-inflammatory syndrome associated with COVID-19 JOURNAL=Frontiers in Medicine VOLUME=Volume 10 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1135695 DOI=10.3389/fmed.2023.1135695 ISSN=2296-858X ABSTRACT=Serum amyloid-A (SAA) is associated with inflammatory disorders such as rheumatoid arthritis, Familial Mediterranean Fever, sarcoidosis, and vasculitis. There is accumulating evidence that SAA is a reliable biomarker for these autoinflammatory and rheumatic diseases and may contribute to their pathophysiology. Hyperinflammatory syndrome associated with COVID-19 is a complex interaction between infection and autoimmunity and elevation of SAA is strongly correlated with severity of the inflammation. In this review we highlight the involvement of SAA in these different inflammatory conditions, consider its potential role and discuss whether it could be a potential target for treatment hyperinflammatory state of COVID-19 with many advantages, and it is expected to be associated with less side effects. Additional studies linking SAA to the pathophysiology of COVID-19 hyper-inflammation and autoimmune conditions are needed to establish the causal relationship, and the therapeutic potential of inhibitors targeting SAA activity are needed.