AUTHOR=Parnow Abdolhossein , Hafedh Muthanna , Tsunoda Ikuo , Patel Darpan I. , Baker Julien S. , Saeidi Ayoub , Bagchi Sovan , Sengupta Pallav , Dutta Sulagna , Łuszczki Edyta , Stolarczyk Artur , Oleksy Łukasz , Al Kiyumi Maisa Hamed , Laher Ismail , Zouhal Hassane 

TITLE=Effectiveness of exercise interventions in animal models of multiple sclerosis

JOURNAL=Frontiers in Medicine

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1143766

DOI=10.3389/fmed.2023.1143766

ISSN=2296-858X

ABSTRACT=Multiple sclerosis (MS) is a condition associated with impaired immune system severely affecting the spinal cord and brain, marked by progressive inflammatory demyelination. Patients with MS may benefit from exercise training as a suggested course of treatment. The most often used animal in studies on MS are experimental autoimmune/allergic encephalomyelitis (EAE) models. The present review intends to concisely discuss the interventions using EAE models to understand the effectiveness of exercise as treatment for MS patients and thereby provide clear perspective for future research and MS management. For the present literature review, relevant published articles on EAE animal model that reported the impacts of exercise on MS, were extracted from various databases. Existing literature support that exercise regimen can reduce the severity of some of the clinical manifestations of EAE, including neurological signs, motor function, pain, and cognitive deficits. Further results demonstrate the mechanisms of EAE suppression with information relating to the immune system, demyelination, regeneration, and exercise in EAE. The role for neurotrophic factors has been also been investigated. Analysing the existing reports, the article infers that EAE is a suitable a beneficial animal model that can help researchers develop further understanding and treatments for MS, and also. Besides, findings from previous animal studies supports the contention that exercise assists in ameliorating MS progression.